| Gene Symbol | ERK1 |
| Chromosome | 16p11.2 |
| Protein Type | Kinase |
| Function | is a serine/threonine protein kinase that plays a central role in intracellular signal transduction. |
| Primary Expression | various tissues, with particularly high levels in the brain where it participates in learning, memory, and neuronal plasticity |
| Subcellular Localization | **: Nuclear import/export controls signaling duration |
| Molecular Weight | 44 kDa |
| Amino Acids | 402 aa |
| Pathways | Akt, Apoptosis, Differentiation, G-Protein Coupled Receptor, Hedgehog |
| Ensembl ID | ENSG00000102882 |
| GeneCards | ERK1 |
| Human Protein Atlas | ERK1 |
| N-lobe | ATP-binding pocket with glycine-rich loop |
| C-lobe | Catalytic site and substrate recognition surface |
| Associated Diseases | AD, Aging, ALI, Als, Alzheimer, AMI |
| Known Drugs/Compounds | curcumin, metformin, rapamycin |
| Interactions | 6-OHDA, ACSL4, AGING, AKT, AKT1, ALZHEIMER |
| KG Connections | 928 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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