gene 888 words KG: RCAN1
Contents

RCAN1 Gene

🧬 Gene Info
Gene SymbolRCAN1
Chromosome21q22.12
Protein TypeGene
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionheart and skeletal muscle - RCAN1
Molecular Weight28 kDa
Exons8
PathwaysCBF Pathway
UniProt IDP53805
NCBI Gene ID1077
Ensembl IDENSG00000100097
GeneCardsRCAN1
Human Protein AtlasRCAN1
N-terminal Calcineurin-binding domainMediates interaction with calcineurin
Proline-rich regionsSupport protein-protein interactions
Associated DiseasesALS, disease, Huntington, Huntington's disease, neurodegeneration, oxidative stress
Known Drugs/CompoundsG2-115, memantine
InteractionsACHE, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, APOPTOSIS,
KG Connections93 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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Related Hypotheses (6)

CYP46A1 Overexpression Gene Therapy
Score: 0.98
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
TREM2-mediated microglial tau clearance enhancement
Score: 0.62

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

NeuRon Therapeutics
company · KG edge: activates
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
GFAP (Redirect)
redirect · KG edge: activates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: activates

Knowledge Graph (12 edges)

RCAN1 activates TNF
RCAN1 associated_with PI3K
RCAN1 associated_with PP2A
RCAN1 activates ERK1
RCAN1 activates NRF2
RCAN1 activates KEAP1
RCAN1 associated_with AKT
RCAN1 regulates CALCINEURIN
RCAN1 inhibits calcineurin
G2-115 inhibits RCAN1

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