| Gene Symbol | DDX58 |
| Full Name | DEAD-Box Helicase 58 |
| Chromosome | 9q34.3 |
| Protein Type | Receptor |
| Function | DDX58 (DEAD-Box Helicase 58), commonly known as RIG-I (Retinoic Acid-Inducible Gene I), is a cytoplasmic pattern recognition receptor (PRR) that detects viral RNA and initiates antiviral immune respon |
| Primary Expression | Ubiquitous, high in immune cells and brain |
| Pathways | Interferon Signaling |
| UniProt ID | [O95786](https://www.uniprot.org/uniprot/O95786) |
| GeneCards | DDX58 |
| Human Protein Atlas | DDX58 |
| RNA sensing | Recognizes 5' triphosphate double-stranded RNA and viral RNA motifs |
| Helicase activity | Unwinds RNA substrates using ATP hydrolysis |
| Signal transduction | Activates downstream signaling cascades |
| Interferon induction | Triggers type I interferon (IFN-α/β) production |
| Antiviral response | Initiates cellular antiviral defenses |
| Associated Diseases | neurodegeneration |
| Interactions | BAX, BECN1, CSF1, HNRNPA1, STAT1 |
| KG Connections | 20 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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