gene 2,272 words KG: PRDM1
Contents

PRDM1 Gene

🧬 Gene Info
Gene SymbolPRDM1
AliasesPRDI-BF1 and RZ-1 Homolog 1/Blimp-1
Chromosome6q21
Protein TypeTranscription Factor
Functionencodes a critical transcriptional repressor that controls plasma cell differentiation, immune cell function, and inflammatory responses.
Molecular Weight105 kDa
Amino Acids982 aa
PathwaysCo-inhibitory Gene Module, Nf-Κb
UniProt IDO75663
NCBI Gene ID639
Ensembl IDENSG00000060656
OMIM603226
GeneCardsPRDM1
Human Protein AtlasPRDM1
Associated DiseasesALS, Diabetes
InteractionsAND, CANCER, CD4, CD8, Cytokine, GENES
KG Connections90 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (8)

Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.72
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66

Related Analyses (6)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

See Also (11)

Apoptosis in Neurodegeneration
entity · KG edge: expressed_in
Genes
index · KG edge: interacts_with
CD4 Gene
gene · KG edge: inhibits
CD44 - Cell Surface Glycoprotein
gene · KG edge: biomarker_for
CD8 Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

MAF inhibits PRDM1
CD8 inhibits PRDM1
CD4 inhibits PRDM1
PRDM1 inhibits CD4
PRDM1 inhibits CD8
CD4 activates PRDM1
CD8 activates PRDM1
CDKN2A regulates PRDM1
TP53 regulates PRDM1
TET2 expressed_in PRDM1

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