gene 2,283 words KG: CASP3
Contents

CASP3 Gene

🧬 Gene Info
Gene SymbolCASP3
Full NameCaspase 3
Chromosome4q34
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight20 kDa
Amino Acids277 aa
PathwaysAkt, Apoptosis, Autophagy, Epigenetic, Glycolysis
UniProt ID[P42574](https://www.uniprot.org/uniprot/P42574)
Ensembl IDENSG00000164305
GeneCardsCASP3
Human Protein AtlasCASP3
Associated DiseasesAging, Als, Alzheimer, Alzheimer_disease, Alzheimer's disease
Known Drugs/CompoundsANTHOCYANINS, aristolochic_acids, Atbc, berberine, BERBERINE, Bpmc
InteractionsABP, ACHE, ACTB, AKT, AKT1, AKT1S1
KG Connections1487 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (27)

Quantum Coherence Disruption in Cellular Communication
Score: 0.63
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Blood-Brain Barrier SPM Shuttle System
Score: 0.53
Gap Junction Hemichannel Modulation for Controlled Mitochond
Score: 0.36
← Prevpg 2/2

Related Analyses (7)

Senescent cell clearance as neurodegeneration therapy
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived

See Also (5)

ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: therapeutic_target
ACTB Gene
gene · KG edge: associated_with
AKT1 Gene
gene · KG edge: inhibits
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: associated_with
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: expressed_in

Knowledge Graph (12 edges)

CASP3 encodes CASPASE3
OPTN interacts_with CASP3
CASP3 regulates AKT1
CASP3 regulates CALCOCO2
CASP3 regulates CGAS
CASP3 regulates CFTR
CASP3 interacts_with SQSTM1
CASP3 interacts_with RPS6KB1
CASP3 interacts_with GRB2
CASP3 interacts_with RHEB

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