concept

CDH5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDH5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

44Connections

0Hypotheses

0Analyses

29Outgoing

15Incoming

2Experiments

0Debates

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💡 Concept Info

Name	CDH5
Key Genes/Proteins	ADM, adrenomedullin, ANGPT1, APC, ARF6, AXIN1

Pathway Diagram

graph TD
    CDH5[CDH5]
    CDH5 -->|regulates| RELN[RELN]
    CDH5 -->|mediates| Reln_Secretion[Reln Secretion]
    CDH5 -->|expressed in| Lymphatic_Endothelial_Cell[Lymphatic Endothelial Cell]
    CDH5 -->|involved_in| reelin_secretion[reelin secretion]
    CDH5 -->|modulates| Lymphatic_Cell_Permeability[Lymphatic Cell Permeability]
    CDH5 -->|modulates| Cytoskeletal_Remodeling[Cytoskeletal Remodeling]
    CDH5 -->|involved_in| Adherens_Junction_Remodeling[Adherens Junction Remodeling]
    CDH5 -->|modulates| Lymphatic_Endothelial_Cell_Per[Lymphatic Endothelial Cell Permeability]
    CDH5 -->|involved_in| tight_junctional_complex[tight junctional complex]
    EXOC1[EXOC1] -->|interacts| CDH5
    ARF6[ARF6] -->|interacts| CDH5
    Paeoniflorin[Paeoniflorin] -->|upregulates| CDH5
    adrenomedullin[adrenomedullin] -->|modulates| CDH5
    exocyst_complex[exocyst complex] -->|mediates| CDH5
    Qingqi_Liangying_formula[Qingqi Liangying formula] -->|upregulates| CDH5
    APC[APC] -->|regulates| CDH5
    AXIN1[AXIN1] -->|regulates| CDH5
    AXIN2[AXIN2] -->|regulates| CDH5

Outgoing (29)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CDH5	data_in	dataset_row	0.00
reelin secretion	involved_in	process	0.95
RELN	regulates	protein	0.95
Reln Secretion	mediates	process	0.95
Lymphatic Endothelial Cell	expressed_in	cell_type	0.95
Lymphatic Cell Permeability	modulates	phenotype	0.90
Cytoskeletal Remodeling	modulates	process	0.90
Adherens Junction Remodeling	involved_in	process	0.90
Lymphatic Endothelial Cell Permeability	modulates	phenotype	0.90
RELN	mediates	protein	0.90
blood-brain barrier	involved_in	process	0.90
tight junctional complex	involved_in	pathway	0.90
Lymphatic Endothelial Cell Secretion	associated_with	process	0.85
Exocyst Complex	interacts_with	protein	0.85
ADM	interacts_with	protein	0.85
ARF6	interacts_with	protein	0.85
cytoskeletal remodeling	regulates	process	0.80
CREBBP	regulates	gene	0.60
CTNNB1	regulates	gene	0.60
EP300	regulates	gene	0.60
FOXM1	regulates	gene	0.60
MUC1	regulates	gene	0.60
MUC16	regulates	gene	0.60
SMARCA4	regulates	gene	0.60
ROS	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
endothelial cells	expressed_in	cell_type	0.60
epigenetic regulation	participates_in	pathway	0.60
CLDN5	associated_with	gene	0.60

Incoming (15)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CDH5	data_in	dataset_row	0.00
ARF6	interacts_with	protein	0.90
EXOC1	interacts_with	protein	0.90
Paeoniflorin	upregulates	compound	0.88
adrenomedullin	modulates	protein	0.85
ARF6	regulates	gene	0.85
exocyst complex	mediates	protein	0.80
Qingqi Liangying formula	upregulates	drug	0.80
AXIN1	regulates	gene	0.60
AXIN2	regulates	gene	0.60
BRG1	regulates	gene	0.60
CBP	regulates	gene	0.60
APC	regulates	gene	0.60
ANGPT1	associated_with	gene	0.60
CDH1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Proximity proteomics of VE-cadherin interactome in lymphatic endotheli	exploratory		0.900	0.00	lymphatic endothelial cells	proposed	N/A
VE-cadherin control of reelin secretion in vitro and in vivo	exploratory		0.850	0.00	lymphatic endothelial cells an	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CDH5 in their description or question text

No additional research found