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ATG16L1 Protein

🔬 Protein Info

Gene Symbol	ATG16L1
Chromosome	2q37.1
Function	is a core autophagy protein essential for autophagosome formation and cellular protein quality control.
Primary Expression	neurons and glial cells throughout the brain, including the cortex, [hippocam
Subcellular Localization	</th><td>Autophagosome membrane, Cytoplasm</td></tr>
Amino Acids	607 aa
Pathways	Akt, Autophagy, Epigenetic, Mapk, Mtor
Ensembl ID	ENSG00000085978
GeneCards	ATG16L1
Human Protein Atlas	ATG16L1
Coiled-Coil Domain (residues 150–300)	Important for homodimerization of ATG16L1. The dimerized form creates a multivalent platform that enhances ATG5 binding.
Mitophagy	ATG16L1 helps target damaged mitochondria for autophagic degradation through interactions with autophagy receptors like p62/SQSTM1 and OPTN.
Aggrephagy	The protein participates in the clearance of protein aggregates, which is particularly important in neurodegenerative diseases.
Xenophagy	ATG16L1 contributes to the degradation of intracellular pathogens.
Synaptic Protein Turnover	Autophagy regulates synaptic protein composition and function at presynaptic and postsynaptic terminals.
Associated Diseases	Inflammation, Intestinal Disease, Osteoarthritis, Parkinson, Rheumatoid Arthritis, Tumor
Known Drugs/Compounds	rapamycin
Interactions	ABP, AIM2, AKT, AKT1, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections	565 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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