concept

AQP3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AQP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

91Connections

0Hypotheses

0Analyses

50Outgoing

23Incoming

0Experiments

0Debates

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💡 Concept Info

Name	AQP3
Key Genes/Proteins	ALZHEIMER, ALZHEIMER'S DISEASE, AND, AQP1, AQP4, AQP5
Related Diseases	Als, ALS, Alzheimer

Pathway Diagram

graph TD
    AQP3["AQP3"]
    AQP3 -->|"expressed in"| Central_Nervous_System["Central Nervous System"]
    AQP3 -->|"activates"| Inflammation["Inflammation"]
    AQP3 -->|"activates"| Pneumonia["Pneumonia"]
    AQP3 -->|"activates"| Infection["Infection"]
    AQP3 -->|"activates"| Tumor["Tumor"]
    AQP3 -->|"activates"| Als["Als"]
    AQP3 -->|"regulates"| Cardiovascular["Cardiovascular"]
    AQP3 -->|"regulates"| Diabetes["Diabetes"]
    AQP3 -->|"regulates"| Heart_Failure["Heart Failure"]
    AQP3 -->|"activates"| MAPK["MAPK"]
    INFLAMMATION["INFLAMMATION"] -->|"activates"| AQP3
    AND["AND"] -->|"activates"| AQP3
    NRF2["NRF2"] -->|"activates"| AQP3
    MST1["MST1"] -->|"expressed in"| AQP3
    AVP["AVP"] -->|"expressed in"| AQP3
    AQUAPORIN_4["AQUAPORIN-4"] -->|"regulates"| AQP3

Outgoing (68)

Target	Relation	Type	Str
Central Nervous System	expressed_in	cell_type	0.90
Als	activates	disease	0.65
Pneumonia	activates	disease	0.65
Infection	activates	disease	0.65
Inflammation	activates	disease	0.65
Cardiovascular	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Heart Failure	regulates	disease	0.65
Tumor	activates	disease	0.65
Als	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Cardiovascular	expressed_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
LOR	regulates	gene	0.60
glycerol transport	involved_in	biological_process	0.60
AND	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
AQP4	expressed_in	gene	0.60
M2 macrophage polarization	enhances	pathway	0.60
AQP1	inhibits	gene	0.60
Endothelial	inhibits	cell_type	0.60
Epithelial	inhibits	cell_type	0.60
AQP5	expressed_in	gene	0.60
AQP5	inhibits	gene	0.60
Endothelial	transports	cell_type	0.60
Epithelial	transports	cell_type	0.60
Ras	inhibits	protein	0.60
cortex	expressed_in	brain_region	0.60
CLDN1	regulates	gene	0.60
ASC	activates	gene	0.60
IL-6	associated_with	gene	0.60
TNF	associated_with	gene	0.60
Nlrp3 Inflammasome	activates	pathway	0.60
Inflammasome	activates	pathway	0.60
Mapk	activates	pathway	0.60
GATA3	activates	gene	0.60
GATA2	activates	gene	0.60
NFATC1	activates	gene	0.60
YAP	expressed_in	gene	0.60
MST2	expressed_in	gene	0.60
HIPPO	activates	gene	0.60
Hippo Pathway	activates	pathway	0.60
AQP4	regulates	gene	0.60
MICROTUBULES	regulates	gene	0.60
Chaperone	regulates	pathway	0.60
MAPK	activates	gene	0.60
AQP4	activates	gene	0.60
GENES	activates	gene	0.60

Incoming (23)

Source	Relation	Type	Str
AQP1	inhibits	gene	0.60
AQP5	transports	gene	0.60
AQP1	transports	gene	0.60
AQP4	transports	gene	0.60
AQP5	expressed_in	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
AQP9	expressed_in	gene	0.60
ASTROCYTE	expressed_in	gene	0.60
AQP1	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
AQP4	inhibits	gene	0.60
AQP5	inhibits	gene	0.60
AND	inhibits	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
INFLAMMATION	activates	gene	0.60
NLRP3	associated_with	gene	0.60
AND	activates	gene	0.60
NRF2	activates	gene	0.60
MST1	expressed_in	gene	0.60
AVP	expressed_in	gene	0.60
AND	regulates	gene	0.60
AQUAPORIN-4	regulates	gene	0.60
AQP4	expressed_in	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AQP3 in their description or question text

No additional research found