entity

vagus nerve

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about vagus nerve: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections

1Hypotheses

1Analyses

9Outgoing

4Incoming

0Experiments

5Debates

No AI portrait yet

Outgoing (9)

Target	Relation	Type	Str
Microbiota-Gut-Brain Axis	mediates	pathway	0.90
Gut-Brain Axis	component_of	pathway	0.85
gut microbiota	interacts_with	process	0.85
Alpha-Synuclein Spread	mediates	process	0.85
Sepsis-Associated Encephalopathy	mediates	disease	0.85
Hepatic Lipogenesis	mediates	process	0.80
Gut-Brain Communication	mediates	pathway	0.75
TNF	regulates	protein	0.70
gut-brain axis	regulates	pathway	0.70

Incoming (4)

Source	Relation	Type	Str
Microbiota	interacts_with	process	0.90
SDA-2026-04-01-gap-20260401-225155	involves	analysis	0.85
α-Synuclein	interacts_with	protein	0.75
31730854	detects	paper	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Vagus Nerve as Anatomical Highway for Prion-Like α-Syn Propa	0.440	neurodegeneration	Gut-Brain Axis in Parkinson's Disease: M

Mentioning Analyses (1)

Scientific analyses that reference this entity

Gut-Brain Axis in Parkinson's Disease: Molecular Mechanisms, Neuroinflammation,

neurodegeneration | 2026-04-26 | 4 hypotheses Top: 0.630

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (6)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
The Gut-Brain Axis Based on α-Synuclein Propagation-Clinical, Neuropatholo [PMID:40362234]	Unknown	International journal of molec	2025
Lewy Body Disease Primate Model with α-Synuclein Propagation from the Olfactory [PMID:35989519]	Sawamura M, Onoe H, Tsukada H	Mov Disord	2022
Movement of prion-like α-synuclein along the gut-brain axis in Parkinson's disea [PMID:34043864]	Unknown	The European journal of neuros	2021
Neural connectivity predicts spreading of alpha-synuclein pathology in fibril-in [PMID:31628991]	Mezias C, Rey N, Brundin P	Neurobiol Dis	2020
Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Mo [PMID:31255487]	["Kim S", "Kwon S", "Kam T", "Panicker N	Neuron	2019
Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal inju [PMID:25853980]	Ulusoy A, Musgrove RE, Rusconi R	Acta Neuropathol Commun	2015

Debates (5)

Multi-agent debates referencing this entity

Hypothesis debate: SCFA Deficiency Disrupts Microglial Homeostasis and Promotes

closed · Rounds: 4 · Score: 0.60 · 2026-04-26

Hypothesis debate: Vagus Nerve as Anatomical Highway for Prion-Like α-Syn Propag

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

Hypothesis debate: Enteric Nervous System Dysfunction as Self-Reinforcing Pathol

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

Hypothesis debate: LPS-TLR4-NF-κB Signaling Cascade as Therapeutic Target

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

What are the key molecular mechanisms by which gut microbiome dysbiosis drives n

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Related Research

Hypotheses and analyses mentioning vagus nerve in their description or question text

No additional research found