protein

FERROPORTIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FERROPORTIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

87Connections

0Hypotheses

0Analyses

50Outgoing

29Incoming

0Experiments

0Debates

Summary

FERROPORTIN is a protein involved in neurodegeneration research. Key relationships include: regulates, transports, expressed in. Associated with Alzheimer, Cancer, Neurodegeneration. Connected to 31 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	FERROPORTIN
Chromosome	2q32.2
Function	Ferroportin serves as the cellular iron export channel
Subcellular Localization	Plasma membrane, Endosomes
Molecular Weight	70 kDa
Amino Acids	571 aa
Pathways	Alpha-Synuclein, Ferroptosis
UniProt ID	[Q9NP59](https://www.uniprot.org/uniprot/Q9NP59)
GeneCards	FERROPORTIN
Human Protein Atlas	FERROPORTIN
12-16 transmembrane helices	Exact topology debated; recent cryo-EM structures show 12 TMs
N-terminal cytoplasmic domain	Contains regulatory phosphorylation sites
Hephaestin/ceruloplasmin binding site	Enables Fe²⁺ oxidation upon export
Hepcidin binding site	Extracellular loop between TM5 and TM6
Enterocytes	DMT1 imports → ferroportin exports dietary iron
Associated Diseases	neurodegeneration
Interactions	AND, DJ-1, HEPCIDIN, TRANSFERRIN
KG Connections	80 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Ferroportin (SLC40A1)

protein · 909 words

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Pathway Diagram

graph TD
    FERROPORTIN["FERROPORTIN"]
    Cancer{"Cancer"}
    FERROPORTIN -->|"regulates"| Cancer
    Tumor{"Tumor"}
    FERROPORTIN -->|"regulates"| Tumor
    Alzheimer{"Alzheimer"}
    FERROPORTIN -->|"regulates"| Alzheimer
    Parkinson{"Parkinson"}
    FERROPORTIN -->|"regulates"| Parkinson
    Neurodegeneration{"Neurodegeneration"}
    FERROPORTIN -->|"regulates"| Neurodegeneration
    TFR1["TFR1"]
    FERROPORTIN -->|"transports"| TFR1
    DMT1["DMT1"]
    FERROPORTIN -->|"transports"| DMT1
    CANCER["CANCER"]
    FERROPORTIN -->|"regulates"| CANCER
    JUN["JUN"]
    FERROPORTIN -->|"regulates"| JUN
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    FERROPORTIN -->|"regulates"| NEURODEGENERATIVE_DISEASES
    ALZHEIMER["ALZHEIMER"]
    FERROPORTIN -->|"regulates"| ALZHEIMER
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    FERROPORTIN -->|"regulates"| PARKINSON_S_DISEASE
    TFR1 -->|"regulates"| FERROPORTIN
    n_6_OHDA["6-OHDA"]
    n_6_OHDA -->|"regulates"| FERROPORTIN
    TFR1 -->|"transports"| FERROPORTIN
    AND["AND"]
    AND -->|"transports"| FERROPORTIN
    DMT1 -->|"transports"| FERROPORTIN
    ALZHEIMER -->|"regulates"| FERROPORTIN
    AND -->|"regulates"| FERROPORTIN
    NEURODEGENERATIVE_DISEASES -->|"regulates"| FERROPORTIN
    JUN -->|"regulates"| FERROPORTIN
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
    ALPHA_SYNUCLEIN -->|"regulates"| FERROPORTIN
    AND -->|"activates"| FERROPORTIN
    DJ_1["DJ-1"]
    DJ_1 -->|"activates"| FERROPORTIN
    style FERROPORTIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (58)

Target	Relation	Type	Str
Iron	mediates	compound	0.95
Iron Transport	mediates	process	0.92
IRON METABOLISM	involved_in	entity	0.90
Iron Metabolism	regulates	process	0.80
Chronic Cerebral Hypoperfusion	inhibits	condition	0.80
Portal Blood	transports	tissue	0.80
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
ALS	regulates	disease	0.65
APOE	regulates	gene	0.60
HIF	regulates	gene	0.60
FERROPTOSIS	regulates	gene	0.60
JUN	regulates	gene	0.60
Ferroptosis	regulates	pathway	0.60
MAP2	regulates	gene	0.60
Ferritin	regulates	protein	0.60
Hemoglobin	regulates	protein	0.60
Transferrin	regulates	protein	0.60
Rb	regulates	protein	0.60
CANCER	regulates	gene	0.60
TFR1	regulates	gene	0.60
Transferrin	transports	protein	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
6-OHDA	regulates	gene	0.60
Macrophage	associated_with	cell_type	0.60
AND	regulates	gene	0.60
AND	activates	gene	0.60
DMT1	associated_with	gene	0.60
DJ-1	activates	gene	0.60
ALPHA-SYNUCLEIN	regulates	gene	0.60
Alpha-Synuclein	regulates	pathway	0.60
TFR1	associated_with	entity	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
AND	transports	gene	0.60
Neuron	regulates	cell_type	0.60
CYTOKINES	regulates	gene	0.60
Hepatocyte	transports	cell_type	0.60
ROS	regulates	gene	0.60
Aβ	regulates	protein	0.60
Cytokine	regulates	protein	0.60
DMT1	transports	gene	0.60
TFR1	transports	gene	0.60
Macrophage	transports	cell_type	0.60
Substantia Nigra	expressed_in	brain_region	0.55

Incoming (29)

Source	Relation	Type	Str
Hepcidin	inhibits	protein	0.95
HEPCIDIN	regulates	entity	0.95
HEPCIDIN	downregulates	protein	0.93
hepcidin	inhibits	protein	0.90
JUN	regulates	gene	0.60
ROS	regulates	gene	0.60
CYTOKINES	regulates	gene	0.60
CANCER	regulates	gene	0.60
TFR1	regulates	gene	0.60
TFR1	transports	gene	0.60
DMT1	transports	gene	0.60
GPX4	regulates	gene	0.60
APOE	regulates	gene	0.60
6-OHDA	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
ALPHA-SYNUCLEIN	regulates	gene	0.60
DJ-1	activates	gene	0.60
PARKINSON	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
DNA	regulates	gene	0.60
DMT1	associated_with	entity	0.60
NRF2	regulates	gene	0.60
NCOA4	regulates	gene	0.60
TFR1	associated_with	gene	0.50
MAP2	regulates	gene	0.50
TRANSFERRIN	regulates	protein	0.50
TRANSFERRIN	associated_with	protein	0.50
TRANSFERRIN	interacts_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FERROPORTIN in their description or question text

No additional research found