gene

EFNB3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EFNB3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5Connections

0Hypotheses

0Analyses

5Outgoing

0Incoming

0Experiments

0Debates

Summary

EFNB3 encodes Ephrin B3, a transmembrane ligand for EPHB receptors involved in synaptic plasticity, axon guidance, and neurodegenerative disease pathophysiology.

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🧬 Gene Info

Gene Symbol	EFNB3
Full Name	Ephrin B3
Chromosome	19p13.3
Function	is a 341-amino acid transmembrane protein with distinctive domains
Amino Acids	341 aa
Pathways	MAPK, PI3K
UniProt ID	[Q99968](https://www.uniprot.org/uniprotkb/Q99968/entry)
Ensembl ID	ENSG00000108947
GeneCards	EFNB3
Human Protein Atlas	EFNB3
Associated Diseases	neurodegeneration
KG Connections	5 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

EFNB3 Gene

gene · 1791 words

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Pathway Diagram

flowchart TD
    N0["EFNB3"]
    N1["senescent cells"]
    N0 -->|"expressed in"| N1
    N2["EPHB6"]
    N0 -->|"implicated in"| N2
    N3["HMGB1"]
    N0 -->|"implicated in"| N3
    N4["SLC24A2"]
    N0 -->|"implicated in"| N4
    N5["WEE1"]
    N0 -->|"implicated in"| N5
    N6["neurodegeneration"]
    N0 -->|"implicated in"| N6

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    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
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    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
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    class N0 gene
    class N1 cell_type
    class N2 gene
    class N3 gene
    class N4 gene
    class N5 gene

Outgoing (5)

Target	Relation	Type	Str
senescent cells	expressed_in	cell_type	0.90
EPHB6	implicated_in	gene	0.60
HMGB1	implicated_in	gene	0.60
SLC24A2	implicated_in	gene	0.60
WEE1	implicated_in	gene	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EFNB3 in their description or question text

No additional research found