gene

EPHB6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EPHB6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4Connections

0Hypotheses

0Analyses

3Outgoing

1Incoming

0Experiments

0Debates

Summary

Gene profile: EPHB6 - atypical ephrin receptor with low kinase activity involved in ephrin signaling, reverse signaling, immune function, and neuronal development. Implicated in Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions through synaptic function, neuroprotection, and immune modulation.

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🧬 Gene Info

Gene Symbol	EPHB6
Full Name	Ephrin Type-B Receptor 6
Aliases	Gene profile: EPHB6
Chromosome	7q34
Protein Type	Receptor
Function	is a member of the Eph receptor tyrosine kinase family, distinguished by its atypical kinase activity.
Primary Expression	immune cells
Pathways	MAPK, PI3K
UniProt ID	Q9WWP6
NCBI Gene ID	2051
GeneCards	EPHB6
Human Protein Atlas	EPHB6
Associated Diseases	neurodegeneration
KG Connections	4 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: EPHB6 — AlphaFold Q9WWP6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

EPHB6 — Ephrin Type-B Receptor 6

gene · 1025 words

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Pathway Diagram

graph TD
    EPHB6["EPHB6"]
    neurodegeneration["neurodegeneration"]
    EPHB6 -->|"implicated in"| neurodegeneration
    Alzheimer_S_Disease{"Alzheimer'S Disease"}
    EPHB6 -->|"implicated in"| Alzheimer_S_Disease
    Neurodegenerative_Conditions{"Neurodegenerative Conditions"}
    EPHB6 -->|"implicated in"| Neurodegenerative_Conditions
    Parkinson_S_Disease{"Parkinson'S Disease"}
    EPHB6 -->|"implicated in"| Parkinson_S_Disease
    Ephrin_Signaling(["Ephrin Signaling"])
    EPHB6 -->|"regulates"| Ephrin_Signaling
    Immune_Function(["Immune Function"])
    EPHB6 -->|"regulates"| Immune_Function
    Immune_Modulation(["Immune Modulation"])
    EPHB6 -->|"regulates"| Immune_Modulation
    Neuronal_Development(["Neuronal Development"])
    EPHB6 -->|"regulates"| Neuronal_Development
    Neuroprotection(["Neuroprotection"])
    EPHB6 -->|"promotes"| Neuroprotection
    Reverse_Signaling(["Reverse Signaling"])
    EPHB6 -->|"regulates"| Reverse_Signaling
    Synaptic_Function(["Synaptic Function"])
    EPHB6 -->|"regulates"| Synaptic_Function
    style EPHB6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Alzheimer_S_Disease fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Parkinson_S_Disease fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Neurodegenerative_Conditions fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Neuroprotection fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f
    style Neuronal_Development fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f
    style Immune_Modulation fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f
    style Ephrin_Signaling fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f
    style Synaptic_Function fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f
    style Immune_Function fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f
    style Reverse_Signaling fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f

Outgoing (3)

Target	Relation	Type	Str
HMGB1	implicated_in	gene	0.60
SLC24A2	implicated_in	gene	0.60
WEE1	implicated_in	gene	0.60

Incoming (1)

Source	Relation	Type	Str
EFNB3	implicated_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EPHB6 in their description or question text

No additional research found