| Gene Symbol | WEE1 |
| Chromosome | 11p15.4 |
| Protein Type | Gene |
| Function | is a nuclear serine/threonine protein kinase that serves as the primary regulator of the G2/M cell cycle checkpoint in mammalian cells[@wee2021]. |
| Subcellular Localization | </strong></td><td>Nucleus</td></tr> |
| Molecular Weight | 70 kDa |
| Amino Acids | 646 aa |
| GeneCards | WEE1 |
| Human Protein Atlas | WEE1 |
| N-terminal lobe | Contains the ATP-binding pocket with the characteristic VAIK motif in subdomain II |
| C-terminal lobe | Provides the substrate-binding surface and contains the activation loop |
| Active site | Located between the two lobes where ATP and substrate bind |
| Associated Diseases | neurodegeneration |
| Interactions | CCL5, CD8, CDK2, C-JUN, CXCL10, DDIT3 |
| KG Connections | 38 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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