gene

CDC25B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDC25B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

22Connections
0Hypotheses
0Analyses
12Outgoing
10Incoming
0Experiments
0Debates

Summary

CDC25B is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, associated with, regulates. Associated with Als, Cancer, Ms. Connected to 19 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolCDC25B
Chromosome20p13
Protein TypePhosphatase
Functionis a dual-specificity protein phosphatase that plays a critical role in regulating cell cycle progression by removing inhibitory phosphates from cyclin-dependent kinases (CDKs)[@cdc2021].
Primary Expressionvarious cancers:
Subcellular Localization**: Nuclear import/export controls
Molecular Weight72 kDa
Amino Acids647 aa
GeneCardsCDC25B
Human Protein AtlasCDC25B
Proliferating cellsHigh expression in dividing cells
BrainLow expression in normal adult brain, upregulated in disease states
TestisHigh expression in spermatogenesis
Embryonic tissuesWidespread expression during development
Cytoplasmic localizationInactive state during interphase
Associated Diseasesneurodegeneration
Known Drugs/Compoundsfarrerol, menadione
InteractionsCdc2, PKCδ
KG Connections22 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CDC25B Gene

gene · 1299 words

Pathway Diagram

graph TD
    CDC25B["CDC25B"]
    Cdc2["Cdc2"]
    CDC25B -->|"activates"| Cdc2
    Als{"Als"}
    CDC25B -->|"biomarker for"| Als
    Ms{"Ms"}
    CDC25B -->|"biomarker for"| Ms
    Cancer{"Cancer"}
    CDC25B -->|"biomarker for"| Cancer
    Tumor{"Tumor"}
    CDC25B -->|"biomarker for"| Tumor
    CD8["CD8"]
    CDC25B -->|"biomarker for"| CD8
    CANCER["CANCER"]
    CDC25B -->|"biomarker for"| CANCER
    GBM["GBM"]
    CDC25B -->|"biomarker for"| GBM
    CDK4["CDK4"]
    CDC25B -->|"associated with"| CDK4
    UHRF1["UHRF1"]
    CDC25B -->|"associated with"| UHRF1
    neurodegeneration["neurodegeneration"]
    CDC25B -->|"implicated in"| neurodegeneration
    indigo_naturalis["indigo naturalis"]
    indigo_naturalis -->|"downregulates"| CDC25B
    PKC_["PKCdelta"]
    PKC_ -->|"phosphorylates"| CDC25B
    farrerol["farrerol"]
    farrerol -->|"binds"| CDC25B
    PI3K_mTOR_inhibitors["PI3K-mTOR inhibitors"]
    PI3K_mTOR_inhibitors -->|"regulates"| CDC25B
    menadione["menadione"]
    menadione -->|"inhibits"| CDC25B
    CD4["CD4"]
    CD4 -->|"biomarker for"| CDC25B
    MMP7["MMP7"]
    MMP7 -->|"associated with"| CDC25B
    MMP1["MMP1"]
    MMP1 -->|"associated with"| CDC25B
    style CDC25B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (12)

TargetRelationTypeStr
benchmark_ot_ad_answer_key:CDC25Bdata_indataset_row0.00
ds-83b31ef18d49provides_data_fordataset1.00
Cdc2activatesprotein0.80
Alsbiomarker_fordisease0.65
Msbiomarker_fordisease0.65

Incoming (10)

SourceRelationTypeStr
benchmark_ot_ad_answer_key:CDC25Bdata_indataset_row0.00
ds-83b31ef18d49data_indataset1.00
indigo naturalisdownregulatesdrug0.90
farrerolbindsdrug0.80
PKCδphosphorylatesprotein0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CDC25B in their description or question text

No additional research found