gene

MAPK7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAPK7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

5Outgoing

9Incoming

0Experiments

0Debates

Summary

Page for MAPK7

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🧬 Gene Info

Gene Symbol	MAPK7
Full Name	Mitogen-Activated Protein Kinase 7
Chromosome	17p11.2
Protein Type	Kinase
Function	MAPK7/ERK5 is activated by upstream MAPKKs, specifically MEK5, which phosphorylates ERK5 at TEY motif within its activation loop [@mekerk].
Primary Expression	the brain with high levels in [@mapk]: - Hippocampus (CA1-CA3 regions) - Cerebral cortex (layer
Pathways	MAPK, MAPK signaling
UniProt ID	[Q13115](https://www.uniprot.org/uniprot/Q13115)
Ensembl ID	ENSG00000166401
OMIM	602534
GeneCards	MAPK7
Human Protein Atlas	MAPK7
Neurogenesis	Controls neural progenitor cell proliferation and differentiation
Synaptic plasticity	Essential for long-term potentiation (LTP) and memory formation
Neuronal survival	Mediates neurotrophic factor signaling (BDNF, NGF)
Associated Diseases	neurodegeneration
KG Connections	14 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MAPK7

gene · 702 words

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Pathway Diagram

flowchart TD
    N0["MAPK7"]
    N1["ABCA7"]
    N1 -->|"expressed in"| N0
    N2["ARF1"]
    N2 -->|"expressed in"| N0
    N3["ATG7"]
    N3 -->|"expressed in"| N0
    N4["E2F2"]
    N4 -->|"expressed in"| N0
    N5["ELAVL1"]
    N5 -->|"expressed in"| N0
    N6["G6PD"]
    N6 -->|"expressed in"| N0
    N7["GRID2"]
    N7 -->|"expressed in"| N0
    N8["MAP"]
    N8 -->|"expressed in"| N0
    N9["MRPS31"]
    N0 -->|"expressed in"| N9
    N10["RIPK2"]
    N0 -->|"expressed in"| N10
    N11["UHRF1"]
    N0 -->|"expressed in"| N11
    N12["necroptosis"]
    N0 -->|"participates in"| N12
    N13["MAPK signaling"]
    N0 -->|"participates in"| N13
    N14["neurodegeneration"]
    N0 -->|"implicated in"| N14

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    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
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    class N0 gene
    class N1 gene
    class N2 gene
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene
    class N9 gene
    class N10 gene
    class N11 gene
    class N12 pathway
    class N13 pathway

Outgoing (5)

Target	Relation	Type	Str
RIPK2	expressed_in	gene	0.60
UHRF1	expressed_in	gene	0.60
MRPS31	expressed_in	gene	0.60
necroptosis	participates_in	pathway	0.60
MAPK signaling	participates_in	pathway	0.60

Incoming (9)

Source	Relation	Type	Str
ABCA7	expressed_in	gene	0.60
ARF1	expressed_in	gene	0.60
ATG7	expressed_in	gene	0.60
E2F2	expressed_in	gene	0.60
ELAVL1	expressed_in	gene	0.60
GRID2	expressed_in	gene	0.60
G6PD	expressed_in	gene	0.60
MAP	expressed_in	gene	0.60
MAPK	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAPK7 in their description or question text

No additional research found