gene 1,634 words KG: TUBB1
Contents

TUBB1 — Tubulin Beta 1

🧬 Gene Info
Gene SymbolTUBB1
Full NameTubulin Beta 1
Chromosome9q34.3
Functionis a gene located on chromosome 9q34.
Primary Expressionmegakaryocytes and platelets, it is also expressed in neurons where it contributes to microtubule assembly, axonal transport, and cytoskeletal stabili
Molecular Weight50 kDa
Amino Acids445 aa
Exons4
Pathwaysoxidative stress response
GeneCardsTUBB1
Human Protein AtlasTUBB1
Middle domain (residues 240-340)Contains binding sites for taxanes and other microtubule-binding agents. TUBB1 has specific residues here that confer sensitivity to certain drugs.
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsAND, CANCER, RNA
KG Connections30 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (3)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Quantum Coherence Disruption in Cellular Communication
Score: 0.63

Related Analyses (3)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (5)

Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Tri
clinical · proposed · Score: 0.40
Brainstem Circuit Modulation for PSP
clinical · proposed · Score: 0.40
Levodopa Response Determinants in PSP — Biomarker-Guided Pre
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
PSP and CBS Biomarker Validation Study
clinical · proposed · Score: 0.40

See Also (7)

Neurodegeneration
disease · KG edge: implicated_in
Genes
index · KG edge: expressed_in
CCL20 Gene
gene · KG edge: therapeutic_target
cxcl8
gene · KG edge: therapeutic_target
HMGCR — 3-Hydroxy-3-Methylglutaryl-CoA Reductase
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

CXCL8 therapeutic_target TUBB1
MMP3 therapeutic_target TUBB1
ICAM1 therapeutic_target TUBB1
HMGCR therapeutic_target TUBB1
CCL20 therapeutic_target TUBB1
MMP3 expressed_in TUBB1
ICAM1 expressed_in TUBB1
CXCL8 expressed_in TUBB1
CCL20 expressed_in TUBB1
TUBB1 expressed_in HMGCR

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