| Gene Symbol | TNFRSF1B |
| Aliases | TNFR2 |
| Protein Type | Receptor |
| Function | encodes a type I membrane receptor for tumor necrosis factor (TNF). |
| Molecular Weight | 75 kDa |
| Amino Acids | 461 aa |
| Exons | 10 |
| Pathways | NF-κB, NF-κB pathway, PI3K, MAPK pathway, MAPK Pathway |
| Ensembl ID | ENSG00000028137 |
| GeneCards | TNFRSF1B |
| Human Protein Atlas | TNFRSF1B |
| [NF-κB](/entities/nf-kb) activation | TNFR2 activates the non-canonical NF-κB pathway via TRAF2/TRAF3, promoting cell survival genes |
| PI3K/Akt pathway | Signals through PI3K to activate Akt, promoting neuronal survival |
| JNK modulation | Unlike TNFR1, TNFR2 does not directly activate pro-apoptotic JNK signaling |
| No death domain | TNFR2 lacks an intracellular death domain, precluding direct apoptotic signaling |
| Associated Diseases | Cancer, Chronic Pain, Leukemia, Lung Cancer, Pain |
| Interactions | ADRA2B, ASTROCYTE, CHRM4, CHRNE, CRH, Cytokine |
| SciDEX Hypotheses | Synaptic Plasticity Preservation |
| KG Connections | 58 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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