| Gene Symbol | SEC22B |
| Full Name | Synaptotagmin Binding Protein |
| Chromosome | 1q21.2 |
| Function | is a member of the SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment Protein Receptor) protein family that plays essential roles in intracellular membrane trafficking. |
| Amino Acids | 215 aa |
| Pathways | Autophagy |
| UniProt ID | [O75396](https://www.uniprot.org/uniprot/O75396) |
| Ensembl ID | ENSG00000169933 |
| OMIM | 607048 |
| GeneCards | SEC22B |
| Human Protein Atlas | SEC22B |
| N-terminal transmembrane region | A short helical transmembrane domain that anchors the protein to vesicle membranes |
| SNARE motif | A conserved region of approximately 60-70 amino acids that participates in SNARE complex formation |
| Proline-rich domain | Located in the central region, involved in protein-protein interactions |
| C-terminal variable region | Contributes to specificity in SNARE pairing |
| Associated Diseases | neurodegeneration |
| Interactions | RTN3, SQSTM1, TH, WDR45, XBP1 |
| KG Connections | 28 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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