| Gene Symbol | PRESENILIN2 |
| Protein Family | Presenilin family, aspartyl proteases |
| Protein Type | Protease |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 50 kDa |
| UniProt ID | O00287 |
| GeneCards | PRESENILIN2 |
| Human Protein Atlas | PRESENILIN2 |
| Nine transmembrane domains | Spanning the membrane |
| Aspartyl protease motif | Two conserved aspartate residues (D257, D263) in transmembrane domains 6 and 7 |
| Large hydrophilic loop | Between transmembrane domains 6 and 7 |
| Amyloid Precursor Protein (APP) | Generates Aβ peptides |
| Notch receptors | Essential for development |
| E-cadherin | Cell adhesion |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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