concept

PPP2R2B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPP2R2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections

0Hypotheses

0Analyses

12Outgoing

17Incoming

0Experiments

0Debates

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💡 Concept Info

Name	PPP2R2B
Key Genes/Proteins	AND, ATG8, AUTOPHAGY, GAPDH, LC3, LC3B
Related Diseases	Als, Ataxia, Huntington's disease, Ms
Related Pathways	Autophagy, autophagy pathway, Mitophagy

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PPP2R2B Gene

gene · 655 words

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Pathway Diagram

graph TD
    PPP2R2B["PPP2R2B"]
    PPP2R2B -->|"regulates"| Ms["Ms"]
    PPP2R2B -->|"regulates"| Als["Als"]
    PPP2R2B -->|"regulates"| Ataxia["Ataxia"]
    PPP2R2B -->|"regulates"| AUTOPHAGY["AUTOPHAGY"]
    PPP2R2B -->|"regulates"| Autophagy["Autophagy"]
    PPP2R2B -->|"regulates"| Mitophagy["Mitophagy"]
    PPP2R2B -->|"implicated in"| neurodegeneration["neurodegeneration"]
    OPTN["OPTN"] -->|"regulates"| PPP2R2B
    PINK1["PINK1"] -->|"regulates"| PPP2R2B
    PARKIN["PARKIN"] -->|"regulates"| PPP2R2B
    PRKN["PRKN"] -->|"regulates"| PPP2R2B
    AND["AND"] -->|"regulates"| PPP2R2B
    PP2A["PP2A"] -->|"regulates"| PPP2R2B
    LC3B["LC3B"] -->|"regulates"| PPP2R2B
    MITOPHAGY["MITOPHAGY"] -->|"regulates"| PPP2R2B

Outgoing (12)

Target	Relation	Type	Str
Ataxia	regulates	disease	0.65
Ms	regulates	disease	0.65
Als	regulates	disease	0.65
autophagy pathway	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
AUTOPHAGY	regulates	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
Autophagy	regulates	pathway	0.60
Mitophagy	regulates	pathway	0.60
Huntington's disease	implicated_in	disease	0.60
PRKN	activates	gene	0.60
PTEN	activates	gene	0.60

Incoming (17)

Source	Relation	Type	Str
AND	regulates	gene	0.60
LC3B	regulates	gene	0.60
MITOPHAGY	regulates	gene	0.60
ATG8	regulates	gene	0.60
LC3B	activates	gene	0.60
GAPDH	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
OPTN	activates	gene	0.60
PINK1	activates	gene	0.60
PPP2CA	activates	gene	0.60
PPP2CB	activates	gene	0.60
LC3	interacts_with	gene	0.60
OPTN	regulates	gene	0.60
PINK1	regulates	gene	0.60
PARKIN	regulates	gene	0.60
PRKN	regulates	gene	0.60
PP2A	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PPP2R2B in their description or question text

No additional research found