gene

PPP2CA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPP2CA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

20Connections

0Hypotheses

0Analyses

13Outgoing

7Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	PPP2CA
Full Name	Protein Phosphatase 2 Catalytic Subunit Alpha
Chromosome	5q31.1
Protein Type	Enzyme
Function	is a 36 kDa protein belonging to the phosphoprotein phosphatase (PPP) family.
Subcellular Localization	, and enzyme activity [@pp2a_structure_1999]. This gene is located on chromosome 5q31.1 and is essential for numerous ce
Molecular Weight	36 kDa
Pathways	Tau Hyperphosphorylation
UniProt ID	[P67775](https://www.uniprot.org/uniprot/P67775)
Ensembl ID	ENSG00000141837
OMIM	176915
GeneCards	PPP2CA
Human Protein Atlas	PPP2CA
Catalytic subunit (C)	PPP2CA or PPP2CB
Scaffold/substrate binding subunit (A)	PR65alpha (PPP2R1A) or PR65beta (PPP2R1B)
Associated Diseases	Alzheimer's Disease
Known Drugs/Compounds	Ficus deltoidea
Interactions	AKT1, GAPDH, LC3B, MAP1LC3B, OPTN, PIK3CA
KG Connections	20 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PPP2CA — Protein Phosphatase 2 Catalytic Subunit Alpha

gene · 1359 words

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Pathway Diagram

graph TD
    PPP2CA["PPP2CA"]
    Als{"Als"}
    PPP2CA -->|"interacts with"| Als
    AKT1["AKT1"]
    PPP2CA -->|"interacts with"| AKT1
    RXRA["RXRA"]
    PPP2CA -->|"interacts with"| RXRA
    RPS6KB1["RPS6KB1"]
    PPP2CA -->|"interacts with"| RPS6KB1
    Akt(["Akt"])
    PPP2CA -->|"interacts with"| Akt
    neurodegeneration["neurodegeneration"]
    PPP2CA -->|"implicated in"| neurodegeneration
    PIK3CA["PIK3CA"]
    PIK3CA -->|"interacts with"| PPP2CA
    style PPP2CA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (13)

Target	Relation	Type	Str
Tau Hyperphosphorylation	regulates	process	0.95
Alzheimer's Disease	associated_with	disease	0.90
Als	interacts_with	disease	0.65
PRKN	activates	gene	0.60
PPP2CB	activates	gene	0.60
Akt	interacts_with	pathway	0.60
PTEN	activates	gene	0.60
PPP2R2B	activates	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
AKT1	interacts_with	gene	0.60
RXRA	interacts_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60

Incoming (7)

Source	Relation	Type	Str
Ficus deltoidea	modulates	compound	0.80
PIK3CA	interacts_with	gene	0.60
GAPDH	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
OPTN	activates	gene	0.60
PINK1	activates	gene	0.60
LC3B	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PPP2CA in their description or question text

No additional research found