protein 565 words KG: PAX6
Contents

PAX6 Protein

🔬 Protein Info
Gene SymbolPAX6
Full NamePaired Box 6
Chromosome11p13
Protein FamilyPaired Box (PAX) Transcription Factor Family
Protein TypeTranscription Factor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionDeveloping eye, Brain (forebrain, cortex, hippocampus), Olfactory epithelium, Pancreas
Subcellular LocalizationNucleus
Molecular Weight46.8 kDa
Amino Acids128 aa
UniProt IDP26367
Ensembl IDENSG00000061676
GeneCardsPAX6
Human Protein AtlasPAX6
Paired Domain (PD)N-terminal 128 aa that binds specific DNA sequences (P6 and P6' sites)
Associated DiseasesAlzheimer, neurodegeneration
InteractionsDNA, GFAP, Rb
KG Connections43 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Agent Input

Related Hypotheses (6)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.92
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (6)

DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: inhibits
Genes
index · KG edge: expressed_in
CDK6 Gene
gene · KG edge: expressed_in
ERN1 — Endoplasmic Reticulum To Nucleus Signaling 1
gene · KG edge: expressed_in
FOXO1 Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

PAX6 regulates CDK6
CDK6 regulates PAX6
PAX6 expressed_in FOXO1
PBX3 expressed_in PAX6
XBP1 expressed_in PAX6
PAX6 expressed_in ERN1
PAX6 expressed_in Progenitor Cell
CDK6 expressed_in PAX6
PAX6 inhibits Rb
GFAP co_expressed_with PAX6

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