gene

NFL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NFL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

301Connections

30Hypotheses

3Analyses

50Outgoing

50Incoming

7Experiments

5Debates

Summary

NFL is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, associated with, therapeutic target. Associated with ALS, Aging, Als. Connected to 169 entities in the SciDEX knowledge graph.

View on Wiki →

AI-generated illustration

Regenerate portrait ↻

🧬 Gene Info

Gene Symbol	NEFL
Full Name	Neurofilament Light Polypeptide
Chromosome	8p21.2
Protein Family	Intermediate filament family
Function	is a neuronal intermediate filament protein encoded by the NEFL gene on chromosome 8p21.
Primary Expression	CNS and PNS neurons (axons)
Molecular Weight	~61.5 kDa
Amino Acids	543 aa
Exons	4
Pathways	Amyloid, ubiquitin-proteasome
UniProt ID	P07196
NCBI Gene ID	4747
Ensembl ID	ENSG00000104825
OMIM	162280
GeneCards	NEFL
Human Protein Atlas	NEFL
Associated Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Dementia
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYOTROPHIC LATERAL SCLEROSIS, AND, APOE
KG Connections	278 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NFL — AlphaFold P07196 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NFL["NFL"]
    NFL -.biomarker for.-> Neurodegeneration["Neurodegeneration"]
    NFL -.biomarker for.-> Neuroinflammation["Neuroinflammation"]
    NFL -.biomarker for.-> Inflammation["Inflammation"]
    NFL -.biomarker for.-> Als["Als"]
    NFL -.biomarker for.-> Aging["Aging"]
    NFL -.biomarker for.-> Alzheimer["Alzheimer"]
    NFL -->|"target for"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    NFL -->|"target for"| Ms["Ms"]
    UCHL1["UCHL1"] -->|"interacts"| NFL
    GFAP["GFAP"] -->|"interacts"| NFL
    TMEM119["TMEM119"] -->|"interacts"| NFL
    SYNAPTOPHYSIN["SYNAPTOPHYSIN"] -.biomarker for.-> NFL
    BACE1["BACE1"] -.biomarker for.-> NFL
    SOD1["SOD1"] -.protects against.-> NFL
    APOE4["APOE4"] -->|"activates"| NFL
    ALS["ALS"] -.biomarker for.-> NFL
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"target for"| NFL
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -.biomarker for.-> NFL

Outgoing (194)

Target	Relation	Type	Str
axonal_integrity	reflects_recovery_of	biological_process	0.00
Alzheimer	biomarker_for	disease	1.00
Als	biomarker_for	disease	1.00
ALZHEIMER'S DISEASE	biomarker_for	gene	1.00
Dementia	biomarker_for	disease	1.00
Neurodegeneration	biomarker_for	process	0.95
Neuro-Axonal Injury	biomarker_for	process	0.95
ALS	biomarker_for	disease	0.95
Als	associated_with	disease	0.95
Neurodegeneration	biomarker_for	disease	0.95
ALS	biomarker_for	disease	0.95
Amyotrophic Lateral Sclerosis	biomarker_for	disease	0.90
Neurological Conditions	associated_with	disease	0.90
Neurodegeneration	biomarker_for	process	0.90
Multiple Sclerosis	associated_with	disease	0.90
Amyotrophic Lateral Sclerosis	associated_with	disease	0.90
Alsfrs-R Rate Of Decline	correlates_with	phenotype	0.90
Survival	correlates_with	phenotype	0.90
DEMENTIA	biomarker_for	gene	0.90
GFAP	biomarker_for	gene	0.90
Functional Decline	associated_with	phenotype	0.85
Aging	biomarker_for	disease	0.85
Neuronal Injury	biomarker_for	mechanism	0.85
Encals Predictor Score	modulates	biomarker	0.85
Aging	associated_with	disease	0.85
Functional Decline	biomarker_for	phenotype	0.85
Als Trial Enrichment	involved_in	process	0.80
Als Trial Stratified Randomisation	involved_in	process	0.80
Neurodegeneration	associated_with	disease	0.75
Als	activates	disease	0.75
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.75
Neuroinflammation	biomarker_for	disease	0.75
Neuropathy	associated_with	disease	0.75
Inflammation	associated_with	disease	0.75
Alzheimer	associated_with	disease	0.75
NEUROINFLAMMATION	biomarker_for	gene	0.70
Neurodegeneration	indicates	mechanism	0.70
oxidative stress response	participates_in	pathway	0.70
GFAP	associated_with	gene	0.70
ALZHEIMER'S DISEASE	associated_with	gene	0.70
Amyotrophic Lateral Sclerosis	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Neuroinflammation	regulates	disease	0.65
Diabetes	biomarker_for	disease	0.65
Hypertension	biomarker_for	disease	0.65
Atherosclerosis	biomarker_for	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65

Incoming (107)

Source	Relation	Type	Str
TAU	biomarker_for	gene	1.00
ALZHEIMER	biomarker_for	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	0.90
AMYLOID	biomarker_for	gene	0.90
Quanterix Simoa	correlates_with	biomarker	0.85
Roche Elecsys	correlates_with	biomarker	0.85
Siemens Healthineers Atellica Im	correlates_with	biomarker	0.85
Fujirebio Lumipulse	correlates_with	biomarker	0.85
NEURODEGENERATION	biomarker_for	gene	0.80
ALS	biomarker_for	gene	0.80
TAU	associated_with	gene	0.74
NEURODEGENERATION	associated_with	gene	0.74
ALZHEIMER	associated_with	gene	0.70
TAU PATHOLOGY	biomarker_for	gene	0.70
CYTOKINES	activates	gene	0.60
TAU PATHOLOGY	activates	gene	0.60
GUT-BRAIN AXIS	associated_with	gene	0.60
MAPT	inhibits	gene	0.60
TMEM106B	interacts_with	gene	0.60
C9ORF72	inhibits	gene	0.60
GRN	inhibits	gene	0.60
DEMENTIA	biomarker_for	gene	0.60
NAD	associated_with	gene	0.60
AMYLOID-BETA	associated_with	gene	0.60
SLEEP-WAKE CYCLE	biomarker_for	gene	0.60
NEURODEGENERATION	interacts_with	gene	0.60
NEUROGRANIN	biomarker_for	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	biomarker_for	gene	0.60
ALZHEIMER DISEASE	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
FTLD	associated_with	gene	0.60
HEXANUCLEOTIDE REPEAT EXPANSIONS	associated_with	gene	0.60
ASTROCYTES	biomarker_for	gene	0.60
MICROGLIA	biomarker_for	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
MIRNAS	biomarker_for	gene	0.60
MYELIN	expressed_in	gene	0.60
ALS	associated_with	gene	0.60
GFAP	associated_with	gene	0.60
EGFR	associated_with	gene	0.60
30283395	elevated in	paper	0.60
AMYOTROPHIC LATERAL SCLEROSIS	biomarker_for	gene	0.60
FUS	therapeutic_target	gene	0.60
MAX	therapeutic_target	gene	0.60
MYELIN	associated_with	gene	0.60
GAIN	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
BRAIN INJURY	causes	gene	0.60
NEUROINFLAMMATION	biomarker_for	gene	0.60

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Plasma NfL Elevation Secondary to BBB-Associated Transport D	0.915	-	What blood-brain barrier permeability ch
Microglial AIM2 Inflammasome as the Primary Driver of TDP-43	0.824	neurodegeneration	What are the mechanisms by which gut mic
Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S	0.822	neurodegeneration	What are the mechanisms by which gut mic
Beta-Hydroxybutyrate Receptor (HCAR2) Signaling Links Ketone	0.808	neurodegeneration	What are the precise temporal dynamics o
Mitochondrial DAMPs-Driven AIM2 Inflammasome Activation in N	0.805	neurodegeneration	What are the mechanisms by which gut mic

Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re	0.804	neurodegeneration	What are the mechanisms by which gut mic
Mitochondrial DNA-Driven AIM2 Inflammasome Activation in Neu	0.803	neurodegeneration	What are the mechanisms by which gut mic
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam	0.789	neurodegeneration	What are the mechanisms by which gut mic
NLRP3 Inhibition (H7): Downstream Inflammatory Reversal	0.780	neurodegeneration	Does restoring neuronal AMPK activity re
SIRT1/PGC-1α Axis Activation to Preserve Mitochondrial Resil	0.778	neurodegeneration	How do gut microbiome-derived metabolite
Hypothesis 2: GPNMB-CD44 Axis as Anti-inflammatory Pathway	0.772	neurodegeneration	View
TLR4 priming is the actionable driver in: How does gut micro	0.753	neurodegeneration	How does gut microbiome dysbiosis contri
plasma LPS-binding protein separates causal from compensator	0.738	neurodegeneration	How does gut microbiome dysbiosis contri
Metabolic Inflexibility Precedes Transcriptional Reprogrammi	0.735	neurodegeneration	What is the optimal therapeutic window f
PDE4 Inhibition as Inflammatory Reset for PD Oligodendrocyte	0.734	neuroinflammation	How do oligodendrocytes initiate neuroin
microglial inflammasome tone defines the therapeutic window	0.720	neurodegeneration	How does gut microbiome dysbiosis contri
NLRP3 Inflammasome Lock Perpetuates Senescence-Associated In	0.720	neurodegeneration	What molecular mechanisms drive microgli
TREM2-APOE4 Axis Drives Metabolic Inflexibility in DAM	0.720	Alzheimer's disease	-
Soluble TREM2 (sTREM2) as Therapeutic Mimic — Decoupling Pha	0.714	Alzheimer's disease	TREM2 agonism vs antagonism in DAM micro
Microglial Disease-Associated States: TREM2-Independent Path	0.710	neurodegeneration	Cell type vulnerability debate in Alzhei
TLR4/MyD88/NF-κB Axis Blockade to Interrupt LPS-Mediated Gut	0.703	neurodegeneration	How do gut microbiome-derived metabolite
TREM2 haploinsufficiency dysregulates microglial synaptic su	0.700	neurodegeneration	Synaptic pruning by microglia in neurode
H5: BET Bromodomain Readers Sense Aberrant Chromatin and Dri	0.690	neurodegeneration	Investigate mechanisms of epigenetic rep
Loss of AQP4 Polarization Impairs Glymphatic Perivascular In	0.690	neurodegeneration	What are the specific molecular mechanis
ω-3 Docosahexaenoic Acid (DHA) Metabolism via 15-Lipoxygenas	0.000	lipidomics	Lipid metabolism dysregulation in Alzhei
LDLR-Targeted Anti-Inflammatory Antibody Delivery for Neuroi	0.000	neuropharmacology	What is the actual quantitative contribu
ABCA1 Upregulation via LXRβ Agonism to Enhance Cholesterol E	0.000	lipidomics	Lipid metabolism dysregulation in Alzhei
CCR2-Mediated Microglial Replacement Drives mTOR-HIF1α Metab	0.000	developmental neurobiology	Do perinatal immune challenges create pe
STING-Mediated NLRP3 Inflammasome Priming in ALS Microglia	0.000	Neuroinflammation	Immune atlas neuroinflammation analysis
ACSL4-Mediated Neuroinflammatory Amplification in Disease-As	0.000	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di

Mentioning Analyses (3)

Scientific analyses that reference this entity

Can CSF p-tau217 normalization serve as a reliable surrogate endpoint for determ

neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.560

Blood-brain barrier permeability changes as early biomarkers for neurodegenerati

neurodegeneration | 2026-04-26 | 5 hypotheses Top: 0.712

Multi-modal Biomarker Panel Design for Early AD Detection

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.535

Experiments (7)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Resveratrol protection against renal I/R injury in diabetic rats	validation	diabetic nephropathy	0.900	streptozotocin-induced diabeti	proposed	N/A
TLR expression analysis in Parkinson's disease patients	clinical	Parkinson's disease	0.850	human patients	proposed	N/A
Resveratrol effects on HK-2 cells under hypoxia/reoxygenation	exploratory	diabetic nephropathy	0.850	HK-2 cells cultured in high gl	proposed	N/A
TLR4 Activation Assay with NETs and Anti-CarP Antibodies	exploratory	rheumatoid arthritis	0.850	HEK293 TLR4 reporter cells	proposed	N/A
PGC-1α knockout analysis of PV+ interneuron maturation	validation	neurodevelopmental disorders	0.850	knockout mice	proposed	N/A
TLR expression in α-synuclein overexpressing mice	validation	Parkinson's disease	0.800	mice overexpressing human α-sy	proposed	N/A
PV+ interneuron subtype diversification analysis	exploratory	neurodevelopmental disorders	0.750	mouse cortical PV+ interneuron	proposed	N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214]	Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia	J Inflamm Res	2022	1
Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiqui [PMID:30966861]	["Han X", "Sun S", "Sun Y", "Song Q", "Z	Autophagy	2020	1
Podocyte TLR4 deletion alleviates diabetic kidney disease through prohibiting PK [PMID:40659086]	Li Z, Tan D, Lin J, Zhang T, Liu B et al	J Adv Res	2026	0
Celastrol treatment attenuates the inflammatory response in Alzheimer's disease [PMID:40762111]	Cao F, Zhang P, Zheng Z, Wang P, Wang Y	Neurol Res	2026	0
CircCramp1l targets the miR-532-3p/HMGB1/Drp1 axis to regulate allergic rhinitis [PMID:41519399]	Zhang Y, Wang J, Song Y, Chai J, Li L et	Biochem Pharmacol	2026	0
Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosi [PMID:41702081]	Qin H, Yang L, Du J, Xu X, Chen Z et al.	Int Immunopharmacol	2026	0
2'-Fucosyllactose Alleviates Metabolic Hypertension in Mice via Gut Microbiota M [PMID:41926238]	Chen J, Liang S, Liu D, Yang S, Yan Q et	J Agric Food Chem	2026	0
Leveraging intraperitoneal delivery of toll-like receptor agonists to treat peri [PMID:41926324]	Yan H, Chia D, Ernst S, Demuytere J, Cos	Expert Opin Drug Deliv	2026	0
Small-molecule PCSK9 inhibition enhances BBB amyloid-β clearance and suppresses [PMID:41927877]	Miao J, Wang J, Zhou W, Guo J	Sci Rep	2026	0
Anti-carbamylated protein antibodies stabilize carbamylated Histone H3 to promot [PMID:41930627]	Nakabo S, Hanata N, Patino-Martinez E, H	Arthritis Rheumatol	2026	0
In silico design of a novel multi-epitope mRNA vaccine candidate for BtHKU5-CoV- [PMID:41931545]	Zheng N, Xu Y	PLoS Negl Trop Dis	2026	0
Upstream ORFs control TNFR1 abundance and tissue tolerance to TNF. [PMID:41931597]	Ma B, Lyu W, Rizk J, Han X, Kjær M et al	Sci Immunol	2026	0
Interweaving microglial senescence and gut microbiome dynamics in Alzheimer's di [PMID:41747877]	Waghmare A, Rahangdale S, Khare K, Taksa	Molecular and cellular neurosc	2026	0
Nanopiezoelectric 3D-Bioprinted Neural Organoid Models Epileptic Neuron-Microgli [PMID:41877549]	Chu J, Hu K, Lee WF, Xu SJ, Sun Z, Xu Y,	Nano letters	2026	0
The Neuroameliorative Effects of Enzymatically Modified Isoquercitrin and Sodium [PMID:41880086]	Hassouna I, Hassanein OH, El-Elaimy IA,	Neurochemical research	2026	0
Role of Pentacyclic Triterpenes in the Management of Neurological Disorders: An [PMID:41870813]	Upadhayay S	Molecular neurobiology	2026	0
Hyperglycaemia-induced metabolic stress and epigenetic imprinting in the inflamm [PMID:41730508]	Razi FB, Ashraf H, Singhal S, Qamar Z, M	Diabetes research and clinical	2026	0
Colonic Barrier Dysfunction and Inflammation Induced by Nano-/Micro-Plastics Fib [PMID:41923296]	Li Y, Bao S, Huang P, Wang J, Li H, Liu	Journal of applied toxicology	2026	0
Artemisinin attenuates 3-nitropropionic acid-induced neurodegeneration via HMGB1 [PMID:41865324]	Mustafa AM, Mudhafar M, Elgindy AM, Esma	Archives of pharmacal research	2026	0
Curcumin and Glycyrrhiza glabra Synergistically Attenuate Alzheimer's Pathology [PMID:41920384]	Liu S, Yan J, Dong J	Neurochemical research	2026	0

Debates (5)

Multi-agent debates referencing this entity

What is the evidence that blood-brain barrier (BBB) permeability changes serve a

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Can CSF p-tau217 normalization serve as a reliable surrogate endpoint for determ

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Blood-brain barrier permeability changes as early biomarkers for neurodegenerati

closed · Rounds: 7 · Score: 0.50 · 2026-04-26

Can a multi-modal biomarker panel combining plasma proteins, neuroimaging featur

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Should clinical practice adopt multi-modal biomarker panels now, or wait for sin

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

Related Research

Hypotheses and analyses mentioning NFL in their description or question text

NFL

Understanding Entity Pages

Summary

Wiki Pages (3)

NfL-Guided Neuroprotection Threshold

Neurofilament Light Chain (NFL)

INFLAMMATION

Pathway Diagram

Outgoing (194)

Incoming (107)

Targeting Hypotheses (30)

Mentioning Analyses (3)

Can CSF p-tau217 normalization serve as a reliable surrogate endpoint for determ

Blood-brain barrier permeability changes as early biomarkers for neurodegenerati

Multi-modal Biomarker Panel Design for Early AD Detection

Experiments (7)

Related Papers (20)

Debates (5)

What is the evidence that blood-brain barrier (BBB) permeability changes serve a

Can CSF p-tau217 normalization serve as a reliable surrogate endpoint for determ

Blood-brain barrier permeability changes as early biomarkers for neurodegenerati

Can a multi-modal biomarker panel combining plasma proteins, neuroimaging featur

Should clinical practice adopt multi-modal biomarker panels now, or wait for sin

Related Research

Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Release Mechanism for

Mitochondrial DNA-Driven AIM2 Inflammasome Activation in Neurodegeneration

Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflammatory Priming

NLRP3 Inhibition (H7): Downstream Inflammatory Reversal

SIRT1/PGC-1α Axis Activation to Preserve Mitochondrial Resiliency Against Microb

Hypothesis 2: GPNMB-CD44 Axis as Anti-inflammatory Pathway

TLR4 priming is the actionable driver in: How does gut microbiome dysbiosis cont

plasma LPS-binding protein separates causal from compensatory states in: How doe

Metabolic Inflexibility Precedes Transcriptional Reprogramming (NAD+/SIRT3 Axis)

PDE4 Inhibition as Inflammatory Reset for PD Oligodendrocytes

microglial inflammasome tone defines the therapeutic window for: How does gut mi

NLRP3 Inflammasome Lock Perpetuates Senescence-Associated Inflammasome Phenotype

Soluble TREM2 (sTREM2) as Therapeutic Mimic — Decoupling Phagocytosis from Infla

Microglial Disease-Associated States: TREM2-Independent Pathways Driving Neuroin