gene 976 words KG: NEK1
Contents

NEK1 — NIMA Related Kinase 1

🧬 Gene Info
Gene SymbolNEK1
Full NameNIMA Related Kinase 1
Chromosome4q33
Protein TypeSerine/Threonine Kinase
FunctionNEK1 is a multifunctional kinase with roles spanning several critical cellular processes.
Primary ExpressionMotor cortex, Spinal cord, Widespread
Molecular Weight145 kDa
UniProt IDQ96PY6
NCBI Gene ID4750
Ensembl IDENSG00000137601
OMIM604588
GeneCardsNEK1
Human Protein AtlasNEK1
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, APOPTOSIS, Ms
InteractionsALS, ANGPTL4, App, C21ORF2, CCNF, CHCHD10
KG Connections99 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (11)

PARP1 Inhibition Therapy
Score: 0.74
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61
VCP-Mediated Autophagy Enhancement
Score: 0.59
Cryptic Exon Silencing Restoration
Score: 0.53
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (9)

Amyotrophic Lateral Sclerosis
redirect · KG edge: regulates
HDAC6 (Redirect)
redirect · KG edge: therapeutic_target
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: therapeutic_target
Genes
index · KG edge: associated_with
C21orf2 — Chromosome 21 Open Reading Frame 2
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CHCHD10 associated_with NEK1
C21ORF2 associated_with NEK1
NEK1 therapeutic_target SOD1
SOD1 therapeutic_target NEK1
TBK1 associated_with NEK1
NEK1 associated_with CHCHD10
HDAC6 therapeutic_target NEK1
TUBULIN causes NEK1
FIG4 causes NEK1
FUS causes NEK1

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