concept

MICROTUBULE STABILITY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MICROTUBULE STABILITY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

35Connections

2Hypotheses

0Analyses

9Outgoing

26Incoming

0Experiments

0Debates

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💡 Concept Info

Name	MICROTUBULE STABILITY

Pathway Diagram

graph TD
    MICROTUBULE_STABILITY["MICROTUBULE STABILITY"]
    MICROTUBULE_STABILITY -->|"involved_in"| Nervous_System_Development["Nervous System Development"]
    MICROTUBULE_STABILITY -->|"involved_in"| Nervous_System_Maintenance["Nervous System Maintenance"]
    MICROTUBULE_STABILITY -->|"regulates"| Neuronal_Cytoskeletal_Architec["Neuronal Cytoskeletal Architecture"]
    MAPT["MAPT"] -->|"inhibits"| MICROTUBULE_STABILITY
    MAP6["MAP6"] -->|"activates"| MICROTUBULE_STABILITY
    MAP6_Rich_Microtubule_Domains["MAP6-Rich Microtubule Domains"] -->|"correlates_with"| MICROTUBULE_STABILITY
    TAU["TAU"] -->|"modulates"| MICROTUBULE_STABILITY

Outgoing (9)

Target	Relation	Type	Str
Nervous System Development	involved_in	process	0.90
Nervous System Maintenance	involved_in	process	0.90
Neuronal Cytoskeletal Architecture	regulates	process	0.90
NEURODEGENERATION	associated_with	entity	0.90
Nervous System Development	contributes_to	process	0.85
Nervous System Maintenance	contributes_to	process	0.85
Neurodegenerative Diseases	associated_with	disease	0.85
neurodegenerative diseases	implicated_in	disease	0.85
morphological plasticity	mediates	phenotype	0.80

Incoming (26)

Source	Relation	Type	Str
MAPT	inhibits	gene	0.95
MAP6	activates	gene	0.95
MAPT	modulates	gene	0.90
MAP6-Rich Microtubule Domains	correlates_with	phenotype	0.90
MAPT	regulates	protein	0.90
MAP6	upregulates	protein	0.90
TAU	modulates	entity	0.90
MAP6	modulates	entity	0.90
MAP6	regulates	gene	0.90
microtubule-targeting drugs	modulates	drug	0.90
Acetylated Tubulin	mediates	protein	0.88
MAP6	promotes	protein	0.88
TAU	regulates	protein	0.85
LRRK2	regulates	gene	0.85
Hdac Inhibitors	promotes	drug	0.85
Microtubule Domains	associated_with	process	0.85
Microtubule-Related Proteins	regulates	protein	0.80
microtubule domains	modulates	protein	0.80
TAU	regulates	entity	0.80
tau	regulates	protein	0.80
HDAC Inhibitors	associated_with	drug	0.80
MAP6	regulates	protein	0.80
Epothilone D	associated_with	drug	0.80
HDAC Inhibitors	upregulates	drug	0.75
GFAP	associated_with	gene	0.70
MAPT	regulates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
HDAC6 Selective Inhibition to Restore Acetylation Balance an	0.643	structural biology	What is the atomic-resolution structure
HDAC6 Inhibition for Dual Restoration of Microtubule Stabili	0.484	neurodegeneration	Which tau PTMs are both disease-specific

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MICROTUBULE STABILITY in their description or question text

No additional research found