| Gene Symbol | LAG3 |
| Aliases | CD223 |
| Protein Type | Receptor |
| Function | LAG3 is primarily expressed on activated T cells, regulatory T cells (Tregs), natural killer cells, and to a lesser extent on B cells and dendritic cells. |
| Molecular Weight | 57 kDa |
| Pathways | Alpha-Synuclein Transmission |
| UniProt ID | [P18627](https://www.uniprot.org/uniprotkb/P18627) |
| GeneCards | LAG3 |
| Human Protein Atlas | LAG3 |
| Extracellular domain | Contains four immunoglobulin-like (Ig-like) domains (D1-D4) with structural homology to CD4 |
| Transmembrane domain | Anchors the protein to the plasma membrane |
| Cytoplasmic tail | Contains a unique "KIEELE" motif essential for inhibitory signaling[@workman2014] |
| Associated Diseases | Cancer, MICROGLIAL ACTIVATION, Parkinson's Disease |
| Interactions | Akt, AKT, alpha-synuclein, ALZHEIMER, AMYLOID, aplp1 |
| KG Connections | 120 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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