gene 2,124 words KG: IL1RL1
Contents

IL1RL1 Gene

🧬 Gene Info
Gene SymbolIL1RL1
Full NameInterleukin-1 Receptor-Like 1 (ST2)
Chromosome2q12
Protein FamilyIL-1 receptor family
Protein TypeReceptor
FunctionEndogenous alarmin signals danger
Primary ExpressionNuclear localization in structural cells
Molecular Weight63 kDa
Amino Acids556 aa
Exons11
PathwaysMAPK
UniProt IDQ9INT6
NCBI Gene ID9173
Ensembl IDENSG00000115607
OMIM601203
GeneCardsIL1RL1
Human Protein AtlasIL1RL1
Associated DiseasesALS
InteractionsADRA1A, ADRA2A, ADRB1, ASTROCYTE, ASTROCYTES, DBH
KG Connections38 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (11)

Optogenetic Control of Mitochondrial Transfer Networks
Score: 0.48
Noradrenergic-Tau Propagation Blockade
Score: 0.71
CYP46A1 Overexpression Gene Therapy
Score: 0.95
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.54

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Astrocytes
cell · KG edge: activates
Microglia
cell · KG edge: activates
Neurodegeneration
disease · KG edge: implicated_in
Astrocytes
entity · KG edge: activates
Microglia in Neurodegeneration
entity · KG edge: activates

Knowledge Graph (12 edges)

IL1RL1 implicated_in AKT
IL1RL1 activates IL33
ADRA1A interacts_with IL1RL1
ADRA2A interacts_with IL1RL1
ADRB1 interacts_with IL1RL1
DBH interacts_with IL1RL1
ERBB4 interacts_with IL1RL1
IL1RL1 interacts_with IL33
IL1RL1 interacts_with NRG1
ACTB regulates IL1RL1

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