gene 2,024 words KG: IL11
Contents

IL11 Gene

🧬 Gene Info
Gene SymbolIL11
Chromosome19q13.4
Protein TypeIL-6 family cytokine
FunctionIL-11 has diverse biological functions spanning multiple organ systems:
Primary Expressionvarious cell types and has been implicated in neuroinflammation, astrocyte function, and neurodegenerative diseases[@du2016][@gadient1998][@schwab2021
Molecular Weight19 kDa
Amino Acids199 aa
PathwaysApoptosis, Metastasis, Tumor Microenvironment, osteoblastogenesis
UniProt IDP20815
NCBI Gene ID3609
OMIM147681
GeneCardsIL11
Human Protein AtlasIL11
Associated Diseasesneurodegeneration
InteractionsAPOPTOSIS, ASTROCYTES, CANCER, CD8, EGFR, IL11R
KG Connections23 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Agent Input

Related Hypotheses (3)

CYP46A1 Overexpression Gene Therapy
Score: 0.98
APOE-Dependent Autophagy Restoration
Score: 0.88
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (13)

JAK Inhibitors in Parkinson's Disease
company · KG edge: associated_with
Neurodegeneration
disease · KG edge: implicated_in
Apoptosis in Neurodegeneration
entity · KG edge: activates
Astrocytes
entity · KG edge: activates
IL6 (Redirect)
redirect · KG edge: associated_with

Knowledge Graph (12 edges)

IL11 interacts_with IL11R
IL11 activates osteoblastogenesis
MTOR associated_with IL11
IL6 associated_with IL11
IL11 associated_with STAT3
EGFR activates IL11
CD8 activates IL11
ERK associated_with IL11
JAK associated_with IL11
CYTOKINES associated_with IL11

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