gene 1,318 words KG: IL1A
Contents

IL1A — Interleukin 1 Alpha

🧬 Gene Info
Gene SymbolIL1A
Full NameInterleukin 1 Alpha
Chromosome2q14.1
FunctionUnlike IL1B which is secreted as a mature protein, IL1A is active in both its pro-form and mature form.
Molecular Weight31 kDa
PathwaysNF-κB, MAPK
GeneCardsIL1A
Human Protein AtlasIL1A
Associated DiseasesAls, Alzheimer, Inflammation
InteractionsALZHEIMER, App, BACE1, BDNF, CANCER, CD14
KG Connections199 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (4)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69

Related Analyses (5)

Which cell types show the most significant expression change
neurodegeneration · completed
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
GBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (10)

BACE1 (Redirect)
redirect · KG edge: associated_with
ACE Gene
gene · KG edge: associated_with
BAX Gene
gene · KG edge: therapeutic_target
BCL2 Gene
gene · KG edge: therapeutic_target
BDNF Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

IL1A activates A1_ASTROCYTES
IL1A activates IMMUNE_RESPONSE
NR4A2 biomarker_for IL1A
CXCL2 biomarker_for IL1A
CSF2 biomarker_for IL1A
STAT3 biomarker_for IL1A
MMP9 biomarker_for IL1A
JAK1 biomarker_for IL1A
HTR3C biomarker_for IL1A
NTS biomarker_for IL1A

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)