disease

hand

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about hand: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

68Connections

3Hypotheses

0Analyses

50Outgoing

9Incoming

0Experiments

0Debates

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Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    hand["hand"]
    TUMOR["TUMOR"]
    hand -->|"regulates"| TUMOR
    Neuroinflammatory["Neuroinflammatory"]
    hand -->|"regulates"| Neuroinflammatory
    FLAVONOIDS["FLAVONOIDS"]
    hand -->|"regulates"| FLAVONOIDS
    GLUCOSE_METABOLISM["GLUCOSE METABOLISM"]
    hand -->|"regulates"| GLUCOSE_METABOLISM
    microglia["microglia"]
    hand -->|"activates"| microglia
    microglia["microglia"]
    hand -->|"regulates"| microglia
    MITOCHONDRIA["MITOCHONDRIA"]
    hand -->|"activates"| MITOCHONDRIA
    Neurodegeneration["Neurodegeneration"]
    hand -->|"inhibits"| Neurodegeneration
    SCHIZOPHRENIA["SCHIZOPHRENIA"]
    hand -->|"inhibits"| SCHIZOPHRENIA
    mTOR["mTOR"]
    hand -->|"inhibits"| mTOR
    ISCHEMIA["ISCHEMIA"]
    hand -->|"inhibits"| ISCHEMIA
    NEURONS["NEURONS"]
    hand -->|"inhibits"| NEURONS
    Proteins["Proteins"]
    hand -->|"associated with"| Proteins
    cancer["cancer"]
    hand -->|"activates"| cancer
    TUMOR["TUMOR"]
    hand -->|"activates"| TUMOR
    Tumor_Microenvironment["Tumor Microenvironment"]
    hand -->|"activates"| Tumor_Microenvironment
    ferroptosis["ferroptosis"]
    hand -->|"associated with"| ferroptosis
    CELL_DEATH["CELL DEATH"]
    hand -->|"associated with"| CELL_DEATH
    Reactive_Oxygen_Species["Reactive Oxygen Species"]
    hand -->|"associated with"| Reactive_Oxygen_Species
    SNAP29["SNAP29"]
    hand -->|"inhibits"| SNAP29
    STX17["STX17"]
    hand -->|"inhibits"| STX17
    VAMP8["VAMP8"]
    hand -->|"inhibits"| VAMP8
    SNARE["SNARE"]
    hand -->|"inhibits"| SNARE
    Pyroptosis["Pyroptosis"]
    hand -->|"activates"| Pyroptosis
    Necroptosis["Necroptosis"]
    hand -->|"activates"| Necroptosis
    Neuron["Neuron"]
    hand -->|"activates"| Neuron
    White_Matter["White Matter"]
    hand -->|"activates"| White_Matter
    MOTOR_NEURON["MOTOR NEURON"]
    hand -->|"activates"| MOTOR_NEURON
    disease["disease"]
    hand -->|"causes"| disease
    Proteins["Proteins"]
    hand -->|"activates"| Proteins

Outgoing (59)

Target	Relation	Type	Str
VAMP8	degrades	entity	0.60
MTOR	inhibits	entity	0.60
MSA	associated_with	entity	0.60
SNAP29	degrades	entity	0.60
STX17	degrades	entity	0.60
PHAGOCYTOSIS	degrades	entity	0.60
NEURODEGENERATION	inhibits	entity	0.60
SCHIZOPHRENIA	inhibits	entity	0.60
NEUROINFLAMMATION	expressed_in	entity	0.60
mTOR	inhibits	entity	0.50
ISCHEMIA	inhibits	disease	0.50
NEURONS	inhibits	concept	0.50
Proteins	associated_with	protein	0.50
TUMOR	activates	disease	0.50
Tumor Microenvironment	activates	process	0.50
CELL DEATH	associated_with	concept	0.50
Reactive Oxygen Species	associated_with	process	0.50
SNARE	inhibits	protein	0.50
Pyroptosis	activates	pathway	0.50
Necroptosis	activates	pathway	0.50
Neuron	activates	cell_type	0.50
White Matter	activates	process	0.50
MOTOR NEURON	activates	concept	0.50
disease	causes	disease	0.50
Proteins	activates	protein	0.50
apoptosis	activates	process	0.50
Ulcerative Colitis	activates	disease	0.50
Autophagy	protects_against	process	0.50
TUMOR	protects_against	disease	0.50
Cardiovascular	protects_against	disease	0.50
disease	protects_against	disease	0.50
aging	activates	phenotype	0.50
White Matter	expressed_in	process	0.50
SYNUCLEIN	inhibits	concept	0.50
Proteins	inhibits	protein	0.50
α-SYNUCLEIN	inhibits	concept	0.50
TUMOR	regulates	disease	0.50
AMYLOID	associated_with	gene	0.50
MITOCHONDRIA	regulates	cell_type	0.50
Astrocytes	regulates	cell_type	0.50
Astrocyte	regulates	cell_type	0.50
cancer	activates	disease	0.50
ferroptosis	associated_with	phenotype	0.50
SNAP29	inhibits	gene	0.50
STX17	inhibits	gene	0.50
VAMP8	inhibits	gene	0.50
MIRO1	regulates	protein	0.50
MIRO1	interacts_with	protein	0.50
PARKIN	associated_with	gene	0.50
PINK1	associated_with	gene	0.50

Incoming (9)

Source	Relation	Type	Str
AUTISM	inhibits	entity	0.60
EPILEPSY	inhibits	entity	0.60
DEPRESSION	associated_with	entity	0.60
ALS	activates	entity	0.60
Neuroinflammation	interacts_with	process	0.50
PHAGOCYTOSIS	regulates	gene	0.50
AUTISM	inhibits	disease	0.50
EPILEPSY	inhibits	gene	0.50
DEPRESSION	associated_with	disease	0.50

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Physiological SCFAs may worsen alpha-synuclein pathology thr	0.550	neurodegeneration	Do physiological concentrations of SCFAs
ABCA7-TREM2 Co-Targeting for Microglial Lipid Handling	0.538	neurodegeneration	Why does the V1613M variant reduce amylo
Reactive astrocyte glutamate-handling failure sustains dendr	0.490	neurodegeneration	Does tau dendritic missorting persist in

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning hand in their description or question text

No additional research found