entity

Mitochondrial dynamics / bioenergetics

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Mitochondrial dynamics / bioenergetics: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections

11Hypotheses

5Analyses

0Outgoing

12Incoming

20Experiments

6Debates

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Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (12)

Source	Relation	Type	Str
CGAS	participates_in	gene	0.54
STING1	participates_in	gene	0.54
DNASE2	participates_in	gene	0.54
COX4I1	participates_in	gene	0.47
TFAM	participates_in	gene	0.46
MIRO1	participates_in	gene	0.43
RAB27A	participates_in	gene	0.41
GJA1	participates_in	gene	0.41
SYNCRIP	participates_in	gene	0.40
GAP43	participates_in	gene	0.38
ALOX5	participates_in	gene	0.36
TRAK1_KIF5A	participates_in	gene	0.34

Targeting Hypotheses (11)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Senescent Cell Mitochondrial DNA Release	0.742	neurodegeneration	Senolytic therapy for age-related neurod
Near-infrared light therapy stimulates COX4-dependent mitoch	0.742	neurodegeneration	Mitochondrial transfer between astrocyte
TFAM overexpression creates mitochondrial donor-recipient gr	0.725	neurodegeneration	Mitochondrial transfer between astrocyte
Mitochondrial Transfer Pathway Enhancement	0.695	neurodegeneration	Astrocyte reactivity subtypes in neurode
CX43 hemichannel engineering enables size-selective mitochon	0.686	neurodegeneration	Mitochondrial transfer between astrocyte

CRISPR-Mediated Mitochondrial Genome Editing for Complex I D	0.681	neurodegeneration	CRISPR-based therapeutic approaches for
RAB27A-dependent extracellular vesicle engineering for mitoc	0.674	neurodegeneration	Mitochondrial transfer between astrocyte
GAP43-mediated tunneling nanotube stabilization enhances neu	0.666	neurodegeneration	Mitochondrial transfer between astrocyte
Mitochondrial RNA Granule Rescue Pathway	0.656	neurodegeneration	RNA binding protein dysregulation across
Mitochondrial SPM Synthesis Platform Engineering	0.647	neurodegeneration	Neuroinflammation resolution mechanisms
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m	0.621	neurodegeneration	Mitochondrial transfer between astrocyte

Mentioning Analyses (5)

Scientific analyses that reference this entity

Mitochondrial transfer between astrocytes and neurons

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.813

RNA binding protein dysregulation across ALS FTD and AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.720

Neuroinflammation resolution mechanisms and pro-resolving mediators

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.784

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.910

Astrocyte reactivity subtypes in neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.741

Experiments (20)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
IRI-AKI mouse model with mtROS inhibition	validation	ischemic acute kidney injury	0.900	0.00	IRI-AKI mice	proposed	N/A
mtROS effects on TFAM and mtDNA in HK2 cells	exploratory	acute kidney injury	0.900	0.00	HK2 cells	proposed	N/A
Cx43 knockdown effects on mitochondrial transfer	exploratory	osteoarthritis	0.900	0.00	human bone marrow-derived MSCs	proposed	N/A
TFAM knockdown functional analysis	exploratory	acute kidney injury	0.850	0.00	HK2 cells	proposed	N/A
Confocal imaging of MSC-chondrocyte interactions during mitochondrial	exploratory	osteoarthritis	0.850	0.00	human bone marrow-derived MSCs	proposed	N/A
TFAM and mtDNA analysis in AKI patients	clinical	acute kidney injury	0.800	0.00	human patients	proposed	N/A
Rab27a knockdown effects on microglia activation in developing brain	validation		0.800	0.00	Neonatal mice with dorsal subv	proposed	N/A
Proposed experiment from debate on Senolytics targeting p16/p21+ senes	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Biomechanical Impact Profiles and Chronic Traumatic Encephalopathy Phe	clinical	Neurodegeneration	0.400	0.50	in_silico	proposed	$180,000
Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk Cohorts	clinical	ALS	0.400	0.50	human	proposed	$6,550,000
cGAS-STING Pathway Validation Study in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,100,000
Mixed Pathology Effects on Parkinson's Disease Progression and Treatme	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
NLRP3 Inflammasome Validation Study in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Regulated Necrosis Validation Study in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Senolytic Therapy (D+Q) Phase IIa Trial in Early Alzheimer's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Traumatic Brain Injury and Alzheimer's Disease Relationship	validation	Alzheimer's Disease	0.400	0.50	human	proposed	$3,000,000
Viral Infections and Alzheimer's Disease — causal mechanisms and thera	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
s:** - Test MCU overexpression specifically in layer II neurons in hea	falsification	Neurodegeneration	0.400	0.50	mouse	proposed	$200,000
Proposed experiment from debate on Mitochondrial transfer between astr	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Mechanism: Selective Vulnerability of Dopaminergic Neurons in Parkinso	validation	Parkinson's Disease	0.400	0.50	human	proposed	$3,000,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic t [PMID:32048886]	Yao RQ, Ren C, Xia ZF, Yao YM	Autophagy	2021	2
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745]	Yu CH, Davidson S, Harapas CR, Hilton JB	Cell	2020	2
Allosteric properties of mammalian ALOX15 orthologs. [PMID:41654134]	Yang J, Borchert A, Kuhn H	J Biol Chem	2026	1
Astrocytic Connexin43 in Alzheimer's disease: mechanisms, interaction with P2 re [PMID:41062060]	Xiong W, Su Y, Verkhratsky A, Yi C	Neuropharmacology	2026	1
Miro1: A potential target for treating neurological disorders. [PMID:40403957]	Zeng L, Yang J, Zhang C, Zhu J, Zhong S,	Neuroscience	2025	1
Connexin43 hemichannel blockade turns microglia neuroprotective and mitigates co [PMID:40595567]	Su Y, Li H, Zhang W, Tao S, Wang Q, Zhan	Nat Commun	2025	1
Imp/IGF2BP and Syp/SYNCRIP temporal RNA interactomes uncover combinatorial netwo [PMID:39919181]	Lee JY, Huang N, Samuels TJ, Davis I	Sci Adv	2025	1
Calcium-Associated Proteins in Neuroregeneration. [PMID:38397420]	Lisek M, Tomczak J, Boczek T, Zylinska L	Biomolecules	2024	1
Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy t [PMID:37651673]	Deng Z, He M, Hu H, Zhang W, Zhang Y, Ge	Autophagy	2024	1
TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic [PMID:38783142]	Liu H, Zhen C, Xie J, Luo Z, Zeng L, Zha	Nat Cell Biol	2024	1
SBFI26 induces triple-negative breast cancer cells ferroptosis via lipid peroxid [PMID:38516826]	He G, Zhang Y, Feng Y, Chen T, Liu M, Ze	J Cell Mol Med	2024	1
Should it stay or should it go: gap junction protein GJA1/Cx43 conveys damaged l [PMID:39394955]	Domingues N, Ribeiro-Rodrigues T, Girão	Autophagy	2024	1
Connexin 43 regulates intercellular mitochondrial transfer from human mesenchyma [PMID:39390589]	Irwin RM, Thomas MA, Fahey MJ, Mayán MD,	Stem Cell Res Ther	2024	1
Mitochondria from osteolineage cells regulate myeloid cell-mediated bone resorpt [PMID:38877020]	Ding P, Gao C, Zhou J, Mei J, Li G, Liu	Nat Commun	2024	1
Increased mitophagy protects cochlear hair cells from aminoglycoside-induced dam [PMID:35471096]	Zhang Y, Fang Q, Wang H, Qi J, Sun S, Li	Autophagy	2023	1
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoi [PMID:37085479]	Herrejon Chavez F, Luo H, Cifani P, Pine	Nat Commun	2023	1
Tumour extracellular vesicles and particles induce liver metabolic dysfunction. [PMID:37225988]	Wang G, Li J, Bojmar L, Chen H, Li Z, To	Nature	2023	1
Selective inhibition of cannabinoid CB(1) receptor-evoked signalling by the inte [PMID:37689260]	Maroto IB, Moreno E, Costas-Insua C, Mer	Neuropharmacology	2023	1
Extracellular vesicles in fatty liver promote a metastatic tumor microenvironmen [PMID:37172577]	Wang Z, Kim SY, Tu W, Kim J, Xu A, Yang	Cell Metab	2023	1
Mitochondrial-derived damage-associated molecular patterns amplify neuroinflamma [PMID:35233090]	Lin MM, Liu N, Qin ZH, Wang Y	Acta Pharmacol Sin	2022	1

Debates (6)

Multi-agent debates referencing this entity

RNA binding protein dysregulation across ALS FTD and AD

closed · Rounds: 4 · Score: 0.72 · 2026-04-12

Astrocyte reactivity subtypes in neurodegeneration

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP

closed · Rounds: 4 · Score: 0.89 · 2026-04-06

SPMs (resolvins, protectins, maresins) from omega-3s may promote inflammation re

closed · Rounds: 4 · Score: 0.83 · 2026-04-06

RNA binding protein dysregulation across ALS FTD and AD

closed · Rounds: 4 · Score: 0.88 · 2026-04-06

Mitochondrial transfer between astrocytes and neurons

closed · Rounds: 4 · Score: 0.95 · 2026-04-06