protein 1,353 words KG: DNAJC5
Contents

DNAJC5 Protein

🔬 Protein Info
Gene SymbolDNAJC5
Chromosome10q24.32
Protein FamilyDnaJ/Hsp40 co-chaperone family
Protein TypeChaperone
Functionis a synaptic molecular chaperone essential for neuronal function and survival.
Subcellular LocalizationSynaptic vesicles, plasma membrane, cytoplasm
Molecular Weight22.4 kDa
Amino Acids198 aa
Exons6
UniProt IDQ9H3X5
NCBI Gene ID80331
Ensembl IDENSG00000170584
GeneCardsDNAJC5
Human Protein AtlasDNAJC5
DnaJ homology domainBinds to Hsp70 chaperones
Associated Diseasesadult-onset neuronal ceroid lipofuscinosis, Als, disease, Huntington, neurodegeneration
InteractionsActin, App, CALB2, GENES, NEURODEGENERATION, Rb
KG Connections55 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (5)

RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (8)

Amyotrophic Lateral Sclerosis
redirect · KG edge: regulates
FUS (Redirect)
redirect · KG edge: causes
ATG7 Gene
gene · KG edge: regulates
CALB2 Gene
gene · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: interacts_with

Knowledge Graph (12 edges)

RAB8A regulates DNAJC5
RAB11A regulates DNAJC5
DNAJC5 regulates ATG7
DNAJC5 regulates VAMP7
DNAJC5 regulates UBIQUITIN
DNAJC5 regulates RAB27A
DNAJC5 causes adult-onset neuronal ceroid lipofuscinosis
DNAJC6 regulates DNAJC5
ROCK2 activates DNAJC5
CALB2 activates DNAJC5

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