protein

CLAUDIN-5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLAUDIN-5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

63Connections

7Hypotheses

1Analyses

47Outgoing

16Incoming

0Experiments

1Debates

Summary

Page for Claudin-5 Protein

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🔬 Protein Info

Gene Symbol	CLAUDIN
Molecular Weight	21.8 kDa
Amino Acids	218 aa
Pathways	Endocytosis
GeneCards	CLAUDIN
Human Protein Atlas	CLAUDIN
Interactions	ALZHEIMER, APP, GFAP, IL-1Β, LRP1, NF-ΚB
KG Connections	57 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    CLAUDIN_5["CLAUDIN-5"]
    GFAP(["GFAP"])
    CLAUDIN_5 -->|"co_discussed"| GFAP
    IL_1_(["IL-1Beta"])
    CLAUDIN_5 -->|"activates"| IL_1_
    NEURON(["NEURON"])
    CLAUDIN_5 -->|"co_discussed"| NEURON
    NF__B(["NF-KappaB"])
    CLAUDIN_5 -->|"activates"| NF__B
    NLRP3(["NLRP3"])
    CLAUDIN_5 -->|"activates"| NLRP3
    OCLN(["OCLN"])
    CLAUDIN_5 -->|"co_discussed"| OCLN
    ALZHEIMER(["ALZHEIMER"])
    ALZHEIMER -->|"co_discussed"| CLAUDIN_5
    AQP4(["AQP4"])
    AQP4 -->|"co_discussed"| CLAUDIN_5
    APP(["APP"])
    APP -->|"activates"| CLAUDIN_5
    style CLAUDIN_5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (47)

Target	Relation	Type	Str
BBB permeability	modulates	mechanism	0.70
TNF	protects_against	protein	0.70
OCCLUDIN	expressed_in	protein	0.50
apoptosis	associated_with	process	0.50
NF-κB	associated_with	concept	0.50
CYTOKINES	associated_with	concept	0.50
Reactive Oxygen Species	associated_with	process	0.50
CELL PROLIFERATION	associated_with	concept	0.50
BBB integrity	protects	process	0.50
GFAP	co_discussed	gene	0.50
IL-1Β	activates	protein	0.50
NEURON	co_discussed	gene	0.50
NF-ΚB	activates	gene	0.50
NLRP3	activates	protein	0.50
OCLN	co_discussed	gene	0.50
PARKIN	co_discussed	gene	0.50
PARKINSON	co_discussed	gene	0.50
SNCA	expressed_in	gene	0.50
WAS	co_discussed	protein	0.50
GENES	co_discussed	gene	0.50
LRP1	co_discussed	gene	0.50
OCCLUDIN	co_discussed	protein	0.50
STROKE	co_discussed	gene	0.50
CAVEOLIN-1	regulates	protein	0.50
Endocytosis	regulates	pathway	0.50
Endothelial Cell	regulates	cell_type	0.50
ENDOTHELIAL	regulates	concept	0.50
ISCHEMIC	regulates	concept	0.50
ISCHEMIC STROKE	regulates	concept	0.50
ENDOTHELIAL CELLS	regulates	concept	0.50
STEM CELLS	regulates	concept	0.50
EXTRACELLULAR VESICLES	regulates	concept	0.50
OCCLUDIN	activates	protein	0.50
EXERCISE	activates	concept	0.50
EXOSOMES	activates	concept	0.50
ENDOTHELIAL	activates	concept	0.50
CELL PROLIFERATION	activates	concept	0.50
PERICYTES	activates	concept	0.50
ENDOTHELIAL CELLS	activates	concept	0.50
OCCLUDIN	inhibits	protein	0.50
Hippocampus	inhibits	entity	0.50
GENE EXPRESSION	inhibits	concept	0.50
Spinal Cord	activates	cell_type	0.50
Proteins	activates	protein	0.50
Proteins	expressed_in	protein	0.50
OCCLUDIN	associated_with	protein	0.50
Proteins	associated_with	protein	0.50

Incoming (16)

Source	Relation	Type	Str
21374818	constitutes	paper	0.90
CLDN5	encodes	gene	0.70
MMP9	interacts_with	protein	0.70
STROKE	regulates	gene	0.50
PHAGOCYTOSIS	activates	gene	0.50
LRP1	activates	gene	0.50
TDP43	activates	protein	0.50
GFAP	activates	gene	0.50
OCLN	associated_with	gene	0.50
GFAP	associated_with	gene	0.50
AQP4	associated_with	gene	0.50
AQUAPORIN-4	associated_with	gene	0.50
ALZHEIMER	co_discussed	gene	0.50
AQP4	co_discussed	gene	0.50
ALZHEIMER	activates	gene	0.50
APP	activates	gene	0.50

Targeting Hypotheses (7)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Gut-BBB Axis: Tributyrin/Butyrate HDAC Inhibition Epigenetic	0.712	-	Blood-brain barrier permeability changes
Plasma Claudin-5 Proteolytic Fragments Distinguish Paracellu	0.705	-	What blood-brain barrier permeability ch
S100B as Active Pathogenic BBB-Disrupting Signal via RAGE/NF	0.647	-	Blood-brain barrier permeability changes
Endothelial miR-181c-5p Upregulation Drives Claudin-5 Repres	0.645	-	What blood-brain barrier permeability ch
Circulating Endothelial Microvesicles Expressing Degraded Cl	0.640	-	What blood-brain barrier permeability ch

Matrix Metalloproteinase-9-Mediated Claudin-5 Cleavage Drive	0.515	-	What blood-brain barrier permeability ch
HBOT at 1.5 ATA for 90 days restores BBB integrity by upregu	0.460	neurodegeneration	What are the optimal oxygen pressure, du

Mentioning Analyses (1)

Scientific analyses that reference this entity

What is the optimal therapeutic window for microglial reprogramming before irrev

neurodegeneration | 2026-04-06 | 7 hypotheses Top: 0.735

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Multiple hypotheses assumed microglia could be restored to homeostatic states, b

closed · Rounds: 4 · Score: 0.63 · 2026-04-22

Related Research

Hypotheses and analyses mentioning CLAUDIN-5 in their description or question text

Matrix Metalloproteinase-9-Mediated Claudin-5 Cleavage Drives Early Tight Juncti

Score: 0.515 · unknown disease · 2026-04-26

Neuroinflammation triggers astrocyte and microglial MMP-9 activation, which proteolytically cleaves claudin-5, the princ

HBOT at 1.5 ATA for 90 days restores BBB integrity by upregulating claudin-5 and

Score: 0.460 · neurodegeneration · 2026-04-25

HBOT promotes pericyte survival via PDGF-BB/PDGFR-β signaling and upregulates claudin-5 transcription through HIF-2α to