disease

Coronary Artery Disease

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Coronary Artery Disease: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

181Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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Disease Info

Associated Genes	AGING, ALDH2, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APOE, APP, CD14
Therapeutic Agents	Anti-Inflammatory Therapies
KG Connections	176 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Pathway Diagram

graph TD
    Coronary_Artery_Disease["Coronary Artery Disease"] -->|"associated"| Heart_Failure["Heart Failure"]
    Coronary_Artery_Disease["Coronary Artery Disease"] -->|"therapeutic target"| Inflammation["Inflammation"]
    Coronary_Artery_Disease["Coronary Artery Disease"] -->|"associated"| Stroke["Stroke"]
    Coronary_Artery_Disease["Coronary Artery Disease"] -->|"activates"| Cholesterol["Cholesterol"]
    Coronary_Artery_Disease["Coronary Artery Disease"] -->|"therapeutic target"| Atherosclerosis["Atherosclerosis"]
    Coronary_Artery_Disease["Coronary Artery Disease"] -->|"associated"| Atherosclerosis_1["Atherosclerosis"]
    Cardiovascular["Cardiovascular"] -->|"associated"| Coronary_Artery_Disease["Coronary Artery Disease"]
    INFLAMMATION["INFLAMMATION"] -->|"therapeutic target"| Coronary_Artery_Disease["Coronary Artery Disease"]
    STROKE["STROKE"] -->|"associated"| Coronary_Artery_Disease["Coronary Artery Disease"]
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"associated"| Coronary_Artery_Disease["Coronary Artery Disease"]
    style Coronary_Artery_Disease fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (54)

Target	Relation	Type	Str
Heart Failure	associated_with	disease	1.00
Inflammation	therapeutic_target	disease	0.95
Stroke	associated_with	disease	0.85
Cholesterol	activates	pathway	0.80
Type 2 Diabetes	activates	disease	0.75
Atherosclerosis	associated_with	disease	0.75
Atherosclerosis	therapeutic_target	disease	0.75
Oxidative Stress	associated_with	pathway	0.70
Heart Failure	activates	disease	0.65
Obesity	associated_with	disease	0.65
Cardiovascular	causes	disease	0.65
Als	causes	disease	0.65
Cardiovascular	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Gut Microbiome	therapeutic_target	pathway	0.60
Nf-Κb	therapeutic_target	pathway	0.60
Oxidative Stress	causes	pathway	0.60
Mitochondrial Function	causes	pathway	0.60
Complement	therapeutic_target	pathway	0.60
Lipid Metabolism	therapeutic_target	pathway	0.60
Immune Response	therapeutic_target	pathway	0.60
Mitochondrial Function	contributes_to	pathway	0.60
Cholesterol	inhibits	pathway	0.60
Cholesterol	causes	pathway	0.60
Complement	causes	pathway	0.60
Cholesterol	associated_with	pathway	0.60
Lipid Metabolism	associated_with	pathway	0.60
Oxidative Stress	regulates	pathway	0.60
Microrna	regulates	pathway	0.60
Arrhythmia	associated_with	disease	0.55
Alzheimer	associated_with	disease	0.55
Stroke	activates	disease	0.55
Stroke	protects_against	disease	0.55
Type 2 Diabetes	causes	disease	0.55
Inflammation	biomarker_for	disease	0.55
Cardiovascular	therapeutic_target	disease	0.55
Stroke	causes	disease	0.55
Insulin Resistance	therapeutic_target	disease	0.55
Diabetes	activates	disease	0.55
Als	associated_with	disease	0.55
Insulin Resistance	associated_with	disease	0.55
Myocardial Infarction	causes	disease	0.55
Myocardial Infarction	associated_with	disease	0.55
Myocardial Infarction	interacts_with	disease	0.55
Atherosclerosis	activates	disease	0.55
Heart Failure	regulates	disease	0.55
Aging	causes	disease	0.55
Atherosclerosis	causes	disease	0.55
Type 2 Diabetes	therapeutic_target	disease	0.55
Longevity	associated_with	disease	0.55

Incoming (127)

Source	Relation	Type	Str
Cardiovascular	associated_with	disease	1.00
INFLAMMATION	therapeutic_target	gene	1.00
CCR9	biomarker_for	gene	0.95
IL13RA1	biomarker_for	gene	0.95
STROKE	associated_with	gene	0.95
MMP9	biomarker_for	gene	0.95
TNFRSF19	biomarker_for	gene	0.90
MSR1	biomarker_for	gene	0.90
Atherosclerosis	causes	disease	0.90
IL-6	associated_with	gene	0.90
Peripheral Immune Cells	associated_with	cell_type	0.85
Immune Response	associated_with	process	0.85
CHIP	risk_factor_for	process	0.85
Anti-Inflammatory Therapies	treats	drug	0.82
IL6	suppresses	gene	0.80
LDLR	associated_with	gene	0.80
IL6	causes	protein	0.80
LDL-C	causes	entity	0.80
INFLAMMATION	associated_with	gene	0.75
APOE	associated_with	gene	0.75
LDL	associated_with	gene	0.75
Diabetes	activates	disease	0.75
OXIDATIVE STRESS	associated_with	gene	0.75
GENES	therapeutic_target	gene	0.75
Als	associated_with	disease	0.75
Hypertension	associated_with	disease	0.75
Myocardial Infarction	associated_with	disease	0.75
Als	therapeutic_target	disease	0.75
INFLAMMATION	biomarker_for	gene	0.65
INSULIN RESISTANCE	therapeutic_target	gene	0.65
ALDH2	associated_with	gene	0.65
STROKE	activates	gene	0.65
DIABETES MELLITUS	activates	gene	0.65
COFFEE	associated_with	gene	0.65
INSULIN RESISTANCE	associated_with	gene	0.65
LDL	inhibits	gene	0.65
STROKE	protects_against	gene	0.65
PROINFLAMMATORY CYTOKINES	inhibits	gene	0.65
CYTOKINES	inhibits	gene	0.65
Als	inhibits	disease	0.65
Aging	associated_with	disease	0.65
Cardiac	associated_with	disease	0.65
PER	associated_with	gene	0.65
Cardiovascular	therapeutic_target	disease	0.65
OXIDATIVE STRESS	causes	gene	0.65
STROKE	causes	gene	0.65
MITOCHONDRIAL DYSFUNCTION	causes	gene	0.65
ROS	causes	gene	0.65
MMP12	associated_with	gene	0.65
PERICYTE	associated_with	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning Coronary Artery Disease in their description or question text

No additional research found