| Gene Symbol | SLC5A1 |
| Aliases | Sodium/Glucose Cotransporter 1 |
| Protein Type | Transporter |
| Function | SLC5A1 serves multiple physiological functions |
| Primary Expression | the brain and may play roles in cerebral glucose metabolism relevant to neurodegenerative diseases |
| Amino Acids | 664 aa |
| UniProt ID | [P13866](https://www.uniprot.org/uniprot/P13866) |
| NCBI Gene ID | 6523 |
| GeneCards | SLC5A1 |
| Human Protein Atlas | SLC5A1 |
| Cerebral Glucose Hypometabolism | AD is characterized by reduced brain glucose utilization, and SGLT1 upregulation may represent a compensatory mechanism.[@an2018] |
| Blood-Brain Barrier | SGLT1 at the BBB may help maintain glucose supply when glucose levels are low.[@nizari2019] |
| Neuronal Vulnerability | Hippocampal neurons expressing SGLT1 may have enhanced survival during metabolic stress.[@yu2010] |
| SGLT Inhibitors | Pharmacological SGLT1 inhibition may worsen or improve AD depending on context and dosing.[@wiciski2020] |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!
No comments yet. Be the first to comment!