concept

RNF216

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RNF216: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections

0Hypotheses

0Analyses

23Outgoing

18Incoming

0Experiments

0Debates

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💡 Concept Info

Name	RNF216
Key Genes/Proteins	Actin, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, App, ATM
Related Diseases	Alzheimer
Related Pathways	Amyloid, Autophagy

Pathway Diagram

graph TD
    RNF216["RNF216"]
    RNF216 -->|"risk_factor_for"| Neurodegeneration["Neurodegeneration"]
    RNF216 -->|"activates"| Alzheimer["Alzheimer"]
    RNF216 -->|"activates"| Tauopathy["Tauopathy"]
    RNF216 -->|"activates"| Autophagy["Autophagy"]
    RNF216 -->|"activates"| NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    RNF216 -->|"activates"| AMYLOID["AMYLOID"]
    RNF216 -->|"activates"| TAUOPATHY["TAUOPATHY"]
    TAUOPATHY -->|"activates"| RNF216
    AMYLOID -->|"activates"| RNF216
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| RNF216
    TRIAD3A["TRIAD3A"] -->|"causes"| RNF216
    ALZHEIMER["ALZHEIMER"] -->|"activates"| RNF216
    TAU["TAU"] -->|"activates"| RNF216
    LC3["LC3"] -->|"activates"| RNF216
    NEURODEGENERATION["NEURODEGENERATION"] -->|"causes"| RNF216

Outgoing (23)

Target	Relation	Type	Str
Neurodegeneration	risk_factor_for	disease	0.90
Alzheimer	activates	disease	0.65
Tauopathy	activates	disease	0.65
Neurodegeneration	causes	disease	0.65
Autophagy	activates	pathway	0.60
LC3	activates	gene	0.60
Rb	activates	protein	0.60
Ubiquitin	activates	protein	0.60
App	activates	protein	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
AMYLOID	activates	gene	0.60
TAUOPATHY	activates	gene	0.60
TAU	activates	gene	0.60
Amyloid	activates	pathway	0.60
AUTOPHAGY	activates	gene	0.60
TRIAD3A	causes	gene	0.60
Actin	activates	protein	0.60
neurodegeneration	causes	disease	0.60
STUB1	associated_with	gene	0.60
WFS1	associated_with	gene	0.60
SETX	associated_with	gene	0.60
FMR1	associated_with	gene	0.60
NEURODEGENERATION	causes	gene	0.60

Incoming (18)

Source	Relation	Type	Str
TAUOPATHY	activates	gene	0.60
AMYLOID	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
TRIAD3A	causes	gene	0.60
ALZHEIMER	activates	gene	0.60
TAU	activates	gene	0.60
LC3	activates	gene	0.60
CLPP	associated_with	gene	0.60
ATM	associated_with	gene	0.60
PNPLA6	associated_with	gene	0.60
POLG	associated_with	gene	0.60
TWNK	associated_with	gene	0.60
LARS2	associated_with	gene	0.60
SIL1	associated_with	gene	0.60
HARS	associated_with	gene	0.60
NEURODEGENERATION	causes	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RNF216 in their description or question text

No additional research found