protein 2,914 words KG: SORL1
Contents

SORL1 Protein

🔬 Protein Info
Gene SymbolSORL1
Full NameSortilin-Related Receptor 1 (Sorterin)
AliasesSortilin-Related Receptor 1
Chromosome11q23.2
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionthe brain, particularly in neurons of the hippocampus, cortex, and cerebel
Molecular Weight250 kDa
Amino Acids214 aa
Exons48
PathwaysAmyloid, Blood-Brain Barrier, Dysbiosis, Endocytosis, Epigenetic
UniProt IDQ92606
NCBI Gene ID6653
Ensembl IDENSG00000137642
OMIM602215
GeneCardsSORL1
Human Protein AtlasSORL1
Associated Diseasesaging, Als, Alzheimer, Alzheimer's disease
InteractionsABCA7, ABCB1, ACE, Actin, ALZHEIMER, ALZHEIMER DISEASE
KG Connections732 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

UniProtWikipedia

Related Hypotheses (30)

TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-Dependent Microglial Senescence Transition
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
VCP-Mediated Autophagy Enhancement
Score: 0.59
Extracellular Vesicle Biogenesis Modulation
Score: 0.58
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54
← Prevpg 2/2

Related Analyses (10)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: associated_with
adam17
gene · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
ABCA7 (Redirect)
redirect · KG edge: associated_with

Knowledge Graph (12 edges)

SOAT1 associated_with SORL1
SORL1 associated_with LRP12
PRKN interacts_with SORL1
SORL1 interacts_with BACE1
SORL1 interacts_with APP
SORL1 interacts_with APOE
SORL1 interacts_with TAU
SORL1 interacts_with SNCA
SORL1 interacts_with SNCAIP
SORL1 interacts_with GSK3B

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.