gene 855 words KG: LRP12
Contents

LRP12 — Low Density Lipoprotein Receptor-Related Protein 12

🧬 Gene Info
Gene SymbolLRP12
Full NameLow Density Lipoprotein Receptor-Related Protein 12
AliasesPage for LRP12
Chromosome8q22.3
Protein TypeReceptor
Functionis a member of the LDL receptor family involved in lipoprotein metabolism, cell signaling, and synaptic function.
Primary Expressionvarious tissues, including brain regions critical for learning and memory [@lrpa]
Molecular Weight182 kDa
Amino Acids2245 aa
UniProt IDQ9Y286
NCBI Gene ID50767
GeneCardsLRP12
Human Protein AtlasLRP12
Ligand-binding repeatsMultiple complement-type repeats that bind various ligands including lipoproteins, apolipoproteins, and extracellular matrix proteins
Transmembrane domainSingle-pass membrane-spanning region
Associated DiseasesAls, Alzheimer, Ms
KG Connections7 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (17)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
LRP1-Dependent Tau Uptake Disruption
Score: 0.58
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.84

Related Analyses (10)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (3)

Anti-Tau Immunotherapy Dosing Optimization
clinical · proposed · Score: 0.40
Tau PET Pattern as Therapeutic Response Predictor in 4R-Tauo
clinical · proposed · Score: 0.40
Tau Propagation Causality Test — Does Tau Spread Drive Neuro
clinical · proposed · Score: 0.40

See Also (15)

SORL1 (Redirect)
redirect · KG edge: associated_with
Neurodegeneration
disease · KG edge: implicated_in
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
Cerebral Amyloid Angiopathy Pathway in Neurodegeneratio
mechanism · Pages share 4 hypotheses

Knowledge Graph (7 edges)

SOAT1 associated_with LRP12
SORL1 associated_with LRP12
LRP12 associated_with Alzheimer
LRP12 associated_with Ms
LRP12 associated_with Als
LRP12 associated_with Cholesterol
LRP12 associated_with Lipid Metabolism

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