protein 2,914 words KG: SORL1
Contents

SORL1 Protein

🔬 Protein Info
Gene SymbolSORL1
Full NameSortilin-Related Receptor 1 (Sorterin)
AliasesSortilin-Related Receptor 1
Chromosome11q23.2
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionthe brain, particularly in neurons of the hippocampus, cortex, and cerebel
Molecular Weight250 kDa
Amino Acids214 aa
Exons48
PathwaysAmyloid, Blood-Brain Barrier, Dysbiosis, Endocytosis, Epigenetic
UniProt IDQ92606
NCBI Gene ID6653
Ensembl IDENSG00000137642
OMIM602215
GeneCardsSORL1
Human Protein AtlasSORL1
Associated Diseasesaging, Als, Alzheimer, Alzheimer's disease
InteractionsABCA7, ABCB1, ACE, Actin, ALZHEIMER, ALZHEIMER DISEASE
KG Connections731 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (30)

APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
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Related Analyses (10)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: associated_with
adam17
gene · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
ABCA7 (Redirect)
redirect · KG edge: associated_with

Knowledge Graph (12 edges)

SOAT1 associated_with SORL1
SORL1 associated_with LRP12
PRKN interacts_with SORL1
SORL1 interacts_with BACE1
SORL1 interacts_with APP
SORL1 interacts_with APOE
SORL1 interacts_with TAU
SORL1 interacts_with SNCA
SORL1 interacts_with SNCAIP
SORL1 interacts_with GSK3B

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