protein 1,373 words KG: SNAP25
Contents

SNAP-25

🔬 Protein Info
Gene SymbolSNAP
AliasesSNAP25
Target ClassStructural Protein
FunctionSnap 25 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Mechanism of ActionProtein cleavage by botulinum toxin or small molecule modulators of SNARE complex formation
DruggabilityLow (0.33)
Clinical StageApproved
GeneCardsSNAP
Human Protein AtlasSNAP
Human Brain ExpressionSearchable expression data across brain regions
Cell Type SpecificityExpression patterns in different neuronal populations
Associated DiseasesAls, Alzheimer, Alzheimer's Disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compoundsrapamycin, RAPAMYCIN
InteractionsACTB, ACTG1, Actin, AD, AKT, ALZHEIMER
SciDEX TargetView Target Profile (2 clinical trials)
SciDEX HypothesesTargeting Synaptic Vesicle Release Machinery to Bl
Synaptic Vesicle Tau Capture Inhibition
Synaptic Vesicle Tau Capture Inhibition
KG Connections655 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (26)

Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Complement C1q Mimetic Decoy Therapy
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69
Ganglioside Rebalancing Therapy
Score: 0.69
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
Synthetic Biology Rewiring via Orthogonal Receptors
Score: 0.65
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Lysosomal Positioning Dynamics Modulation
Score: 0.69
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
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Related Analyses (12)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (6)

Prion Strain Diversity and Selective Vulnerability
clinical · proposed · Score: 0.40
Tau PET Pattern as Therapeutic Response Predictor in 4R-Tauo
clinical · proposed · Score: 0.40
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Alpha-Synuclein Spreading Mechanism — Prion-Like Propagation
exploratory · proposed · Score: 0.40
Cognitive Reserve Mechanisms in Alzheimer's Disease — Molecu
clinical · completed · Score: 0.40

See Also (5)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
ACTB Gene
gene · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
Packard Center for ALS Research
institution · KG edge: associated_with

Knowledge Graph (12 edges)

SNAP25 regulates Synaptic Vesicle Tau Capture Inhibition
ACTB activates SNAP25
LAMP1 associated_with SNAP25
MTOR associated_with SNAP25
LC3 associated_with SNAP25
TUBB3 associated_with SNAP25
ATG7 activates SNAP25
JUN activates SNAP25
SQSTM1 associated_with SNAP25
MAP2 associated_with SNAP25

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