| Gene Symbol | OPTN |
| Full Name | Optineurin |
| Chromosome | 10p13 |
| Protein Type | Adaptor Protein |
| Function | is a 66 kDa coiled-coil domain-containing protein encoded by the OPTN gene on chromosome 10p13. |
| Primary Expression | Motor cortex, Spinal cord, Retina, Brain |
| Subcellular Localization | </strong></td><td>Cytoplasm, Golgi, mitochondria, nucleus</td></tr> |
| Molecular Weight | 66 kDa |
| Amino Acids | 577 aa |
| Pathways | Akt, Amyloid, Apoptosis, Autophagy, Immune Response |
| UniProt ID | Q96CV9 |
| NCBI Gene ID | 10133 |
| Ensembl ID | ENSG00000123240 |
| OMIM | 602432 |
| GeneCards | OPTN |
| Human Protein Atlas | OPTN |
| Associated Diseases | AD, Aging, ALI, Als, Alzheimer |
| Known Drugs/Compounds | DEFERIPRONE, dimethyl fumarate, loganin, rapamycin, RAPAMYCIN |
| Interactions | ABCD3, ABP, ACAT1, ACHE, ACSL4, ACTB |
| SciDEX Hypotheses | OPTN/TBK1 mutations create selective vulnerability |
| KG Connections | 2509 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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