| Gene Symbol | DRP1 |
| Protein Type | Enzyme |
| Function | The DRP1 gene encodes a 736-amino acid GTPase |
| Pathways | Apoptosis, Autophagy, Cell Cycle, Complement, Dna Methylation |
| Ensembl ID | ENSG00000141971 |
| GeneCards | DRP1 |
| Human Protein Atlas | DRP1 |
| N-terminal GTPase domain | Catalyzes GTP hydrolysis (residues 1-300) |
| Middle domain | Mediates self-assembly and dimerization |
| GTPase effector domain (GED) | Stimulates GTPase activity upon oligomerization |
| C-terminal variable region | Determines mitochondrial recruitment and interactions |
| Fis1 | Tail-anchored protein that serves as a minimal DRP1 receptor |
| MiD49/MiD50 | Mitochondrial dynamics proteins that enhance DRP1 recruitment |
| MFF | Mitochondrial fission factor, the primary DRP1 receptor in most tissues |
| Associated Diseases | AD, Aging, ALI, Als, Alzheimer |
| Known Drugs/Compounds | ginsenoside Re, Ginsenoside Re, Mdivi-1, Palmitic Acid, propionic acid, Rg1 |
| Interactions | ABCD3, ABCG2, Actin, ADORA2A, AGING, AKT |
| KG Connections | 1691 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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