protein 1,238 words KG: CSF1R
Contents

CSF1R Protein (Colony Stimulating Factor 1 Receptor)

🔬 Protein Info
Gene SymbolCSF1R
Full NameColony Stimulating Factor 1 Receptor
Chromosome5q32
Protein TypeReceptor
FunctionUpon ligand binding, CSF1R undergoes
Primary ExpressionMicroglia, Macrophages, Osteoclasts, Placenta
Molecular Weight107.6 kDa
Amino Acids972 aa
PathwaysPI3K
UniProt IDP07333
NCBI Gene ID1436
Ensembl IDENSG00000182578
OMIM164770
GeneCardsCSF1R
Human Protein AtlasCSF1R
Associated DiseasesAls, Alzheimer, Anxiety, Atherosclerosis, cancer
Known Drugs/Compoundsdasatinib, KETAMINE, nicotinamide, NICOTINAMIDE, PLX3397, PLX5622
InteractionsABL1, ABL2, ACHE, ACT001, Actin, AD
SciDEX HypothesesCSF1R Inhibition-Mediated Microglial Replacement a
Microglial Phenotypic Polarization via CSF1R-Media
KG Connections701 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (47)

RNA Granule Nucleation Site Modulation
Score: 0.66
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.58
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
Cryptic Exon Silencing Restoration
Score: 0.53
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53
Microglia-Derived Extracellular Vesicle Engineering for Targ
Score: 0.48
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.90
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
Aquaporin-4 Polarization Rescue
Score: 0.73
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
← Prevpg 2/3Next →

Related Analyses (27)

Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · completed
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

Related Experiments (4)

TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.45
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
FTD Microglia Role: Protective vs Destructive Mechanism Stud
validation · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (6)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
AIF1 Gene
gene · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
Packard Center for ALS Research
institution · KG edge: associated_with

Knowledge Graph (12 edges)

CSF1R activates STAT5
TYK2 contributes_to CSF1R
PTK2B contributes_to CSF1R
IL7R contributes_to CSF1R
JAK2 activates CSF1R
PDGFRB activates CSF1R
NTRK3 contributes_to CSF1R
PLX3397 inhibits CSF1R
CSF1R contributes_to TYK2
NRBP1 inhibits CSF1R

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