protein 1,238 words KG: CSF1R
Contents

CSF1R Protein (Colony Stimulating Factor 1 Receptor)

🔬 Protein Info
Gene SymbolCSF1R
Full NameColony Stimulating Factor 1 Receptor
Chromosome5q32
Protein TypeReceptor
FunctionUpon ligand binding, CSF1R undergoes
Primary ExpressionMicroglia, Macrophages, Osteoclasts, Placenta
Molecular Weight107.6 kDa
Amino Acids972 aa
PathwaysPI3K
UniProt IDP07333
NCBI Gene ID1436
Ensembl IDENSG00000182578
OMIM164770
GeneCardsCSF1R
Human Protein AtlasCSF1R
Associated DiseasesAls, Alzheimer, Anxiety, Atherosclerosis, cancer
Known Drugs/Compoundsdasatinib, KETAMINE, nicotinamide, NICOTINAMIDE, PLX3397, PLX5622
InteractionsABL1, ABL2, ACHE, ACT001, Actin, AD
SciDEX HypothesesTREM2-Independent Microglial Activation via CSF1R
CSF1R Inhibition-Mediated Microglial Replacement a
Microglial Phenotypic Polarization via CSF1R-Media
KG Connections704 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (47)

Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.88
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74
PARP1 Inhibition Therapy
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Autophagosome Maturation Checkpoint Control
Score: 0.71
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
Context-Dependent CRISPR Activation in Specific Neuronal Sub
Score: 0.68
Complement C1q Subtype Switching
Score: 0.66
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Related Analyses (27)

Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · completed
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

Related Experiments (4)

TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.45
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
FTD Microglia Role: Protective vs Destructive Mechanism Stud
validation · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (6)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
AIF1 Gene
gene · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
Packard Center for ALS Research
institution · KG edge: associated_with

Knowledge Graph (12 edges)

CSF1R activates STAT5
TYK2 contributes_to CSF1R
PTK2B contributes_to CSF1R
IL7R contributes_to CSF1R
JAK2 activates CSF1R
PDGFRB activates CSF1R
NTRK3 contributes_to CSF1R
PLX3397 inhibits CSF1R
CSF1R contributes_to TYK2
NRBP1 inhibits CSF1R

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