| Gene Symbol | TYK2 |
| Full Name | Tyrosine Kinase 2 |
| Chromosome | 19p13.2 |
| Protein Type | Receptor |
| Function | TYK2 encodes tyrosine kinase 2, a non-receptor tyrosine kinase that belongs to the Janus kinase (JAK) family. |
| Primary Expression | immune cells including microglia, macrophages, and lymphocytes |
| Pathways | JAK-STAT |
| UniProt ID | [P29597](https://www.uniprot.org/uniprot/P29597) |
| Ensembl ID | ENSG00000105397 |
| OMIM | 176941 |
| GeneCards | TYK2 |
| Human Protein Atlas | TYK2 |
| TYK2 inhibitors | Tofacitinib, BMS-986202 for reducing neuroinflammation |
| JAK-STAT modulators | Targeting downstream signaling |
| Immunomodulatory therapy | For neuroinflammation in AD/PD |
| Associated Diseases | Als, Crohn'S Disease, Ms |
| Interactions | ABL1, ABL2, App, CRLF2, Cytokine, EPOR |
| KG Connections | 126 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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