protein 1,174 words KG: CCL5
Contents

CCL5 Protein

🔬 Protein Info
Gene SymbolCCL5
Chromosome17q12
FunctionGαi-mediated inhibition of adenylate cyclase
Subcellular Localization</b></td><td>Secreted, extracellular</td></tr>
Molecular Weight8 kDa
Amino Acids91 aa
PathwaysPI3K, MAPK pathway, PI3K pathway
UniProt IDP08246
NCBI Gene ID6352
Ensembl IDENSG00000161570
OMIM187011
GeneCardsCCL5
Human Protein AtlasCCL5
Associated DiseasesAging, Als, Alzheimer, Cancer, Cirrhosis
InteractionsACTB, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AND, AUTOPHAGY
KG Connections455 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Agent Input

Related Hypotheses (9)

APOE-Dependent Autophagy Restoration
Score: 0.88
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
Aquaporin-4 Polarization Rescue
Score: 0.73
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54

Related Analyses (9)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

See Also (10)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
Astrocytes
entity · KG edge: protects_against
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: protects_against
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
ANG — Angiogenin
gene · KG edge: associated_with

Knowledge Graph (12 edges)

FIP200 inhibits CCL5
CXCL10 activates CCL5
STING activates CCL5
CGAS activates CCL5
IRF3 activates CCL5
CCL5 activates VDAC1
CCL5 activates TBK1
CCL5 activates CCR5
CCL5 activates CCL4
CCL5 activates CCL3

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