| Gene Symbol | BACE1 |
| Full Name | Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 |
| Chromosome | 11q13.2 |
| Protein Type | Protease |
| Target Class | Protease |
| Function | BACE1 is a transmembrane aspartyl protease that catalyzes the ectodomain shedding of numerous type I membrane proteins |
| Mechanism of Action | Small molecule inhibitor of aspartyl protease activity |
| Druggability | Medium (0.48) |
| Clinical Stage | Phase III |
| Pathways | Amyloid, Apoptosis, Lipid Metabolism, Nf-Κb, Synaptic Plasticity |
| UniProt ID | Q15118 |
| NCBI Gene ID | 23626 |
| Ensembl ID | ENSG00000186318 |
| OMIM | 604252 |
| GeneCards | BACE1 |
| Human Protein Atlas | BACE1 |
| Associated Diseases | acute cognitive effects, AD, aging, Als, Alzheimer |
| Known Drugs/Compounds | aducanumab, BACE1 siRNA, DHA, Ginsenosides Rh4, lecanemab, Liquiritigenin |
| Interactions | ABCA1, ABCA7, ACE, ACETYL-COA, ACHE, Actin |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Palmitoylation-Targeted BACE1 Trafficking Disrupto |
| KG Connections | 1577 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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