gene 978 words KG: MAX
Contents

MAX — MAX Protein

🧬 Gene Info
Gene SymbolMAX
Full NameMAX Protein
Chromosome14q23.3
Protein FamilybHLH-LZ Transcription Factor Family
Protein TypeTranscription Factor
FunctionMYC-MAX heterodimers activate target genes
Subcellular LocalizationNuclear
Molecular Weight18 kDa
Amino Acids160 aa
PathwaysTgf-Β
UniProt IDP61275
GeneCardsMAX
Human Protein AtlasMAX
Associated DiseasesAging, Als, Autoimmune, Cancer, Ms
InteractionsApp, AQP4, AQUAPORIN-4, ASTROCYTE, CANCER, CGAS
KG Connections209 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Agent Input

Related Hypotheses (18)

Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
PARP1 Inhibition Therapy
Score: 0.74
Aquaporin-4 Polarization Rescue
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Nucleolar Stress Response Normalization
Score: 0.65
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (8)

BACE1 (Redirect)
redirect · KG edge: associated_with
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: transports
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_with
AQP4 (Aquaporin-4 Gene)
gene · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: debate_co_mention

Knowledge Graph (12 edges)

MAX inhibits CGAS
MAX inhibits STING
MAX inhibits PARP1
MAX inhibits IRF3
DRP1 regulates MAX
TOMM20 regulates MAX
MAX regulates MIRO1
MAX regulates MID51
MAX regulates MID49
MAX regulates MFF

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