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biomarker 1,419 words KG: NFL
Contents

Neurofilament Light Chain (NfL) in Blood - Biomarker

🔬 Protein Info
Gene SymbolNEFL
Full NameNeurofilament Light Polypeptide
Chromosome8p21.2
Protein FamilyIntermediate filament family
Functionis a neuronal intermediate filament protein encoded by the NEFL gene on chromosome 8p21.
Primary ExpressionCNS and PNS neurons (axons)
Molecular Weight~61.5 kDa
Amino Acids543 aa
Exons4
PathwaysAmyloid, ubiquitin-proteasome
UniProt IDP07196
NCBI Gene ID4747
Ensembl IDENSG00000104825
OMIM162280
GeneCardsNEFL
Human Protein AtlasNEFL
Associated DiseasesAging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Dementia
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYOTROPHIC LATERAL SCLEROSIS, AND, APOE
KG Connections278 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (19)

Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.78Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.70Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A
Score: 0.67Microbial Inflammasome Priming Prevention
Score: 0.65Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cro
Score: 0.64Vagal Afferent Microbial Signal Modulation
Score: 0.62Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75APOE Isoform Expression Across Glial Subtypes
Score: 0.74Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69Synaptic Vesicle Tau Capture Inhibition
Score: 0.55Blood-Brain Barrier SPM Shuttle System
Score: 0.53Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (10)

Astrocyte Reactivity Subtypes in Neurodegeneration
neurodegeneration · archivedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · completedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (7)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · proposed · Score: 0.90Blood Biomarker vs Tau PET for Treatment Monitoring
clinical · proposed · Score: 0.40TLR4 Activation Assay with NETs and Anti-CarP Antibodies
exploratory · proposed · Score: 0.85

See Also (4)

Amyotrophic Lateral Sclerosis
redirect · KG edge: associated_withAmyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activatesAlzheimer Indonesia
institution · KG edge: activatesPackard Center for ALS Research
institution · KG edge: associated_with

Knowledge Graph (12 edges)

UCHL1 interacts_with NFL
GFAP interacts_with NFL
TMEM119 interacts_with NFL
SYNAPTOPHYSIN biomarker_for NFL
BACE1 biomarker_for NFL
NFL interacts_with GFAP
NFL biomarker_for BACE1
NFL biomarker_for NEUROGRANIN
NFL biomarker_for TAU
SOD1 associated_with NFL

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