| Gene Symbol | TPX2 |
| Function | TPX2 (Targeting Protein for Xklp2) is a microtubule-associated protein that functions as a key regulator of microtubule nucleation during mitosis[@wittmann2000]. |
| Primary Expression | lung, breast, ovarian, pancreatic cancers[@gingold2014] - Prognostic marker: High expression correlates with poor prognosis[@suitters2007] - The |
| Pathways | Autophagy, Angiogenesis |
| UniProt ID | Q9ULW0 |
| Ensembl ID | ENSG00000178999 |
| GeneCards | TPX2 |
| Human Protein Atlas | TPX2 |
| Microtubule nucleation | TPX2 triggers microtubule formation from γ-TuRC complexes[@tulu2006] |
| Spindle assembly | Recruits and activates Aurora A kinase at spindle poles[@tsai2003] |
| Kinesin-5 inhibition | Controls spindle dynamics by modulating Eg5/kinesin-5 activity[@mayer1999] |
| Chromosome alignment | Facilitates proper kinetochore-microtubule attachments[@obrien2008] |
| Multiple cancers | TPX2 overexpressed in lung, breast, ovarian, pancreatic cancers[@gingold2014] |
| Prognostic marker | High expression correlates with poor prognosis[@suitters2007] |
| Therapeutic target | TPX2 as biomarker and potential target[@tan2015] |
| Associated Diseases | Als, Ataxia, Infection |
| Interactions | AKT, AND, ATM, ATR, AURKA, AUTOPHAGY |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!